PURPOSE: The aim of this study was to characterize the taste changes and taste bud atrophy observed in the period of neutropenia of HCT and to determine the influence of transplantation toxicity on these changes. METHODS: Autologous and allogeneic HCT patients (n = 51) were selected to perform taste acuity tests prior to conditioning (T0) and during neutropenia (T1). The frequency and time duration of oral mucositis, presence of tongue depapillation, and salivary flow rate were also evaluated. Quality of life was assessed using specific questionnaires. RESULTS: We observed a significant increase in hypogeusia (66.6%, p = 0.001) and dysgeusia (21.4%, p = 0.013) at T1, compared with T0. Bitter taste was the most altered, mainly when the patient underwent conditioning with melphalan (OR = 4.47, p = 0.049). Prolonged oral mucositis (≥ 8 days) (OR = 5.62, p = 0.039) and autologous transplantation (OR = 4.08, p = 0.033) were predictive factors for tongue depapillation. Changes in sour taste (OR = 10.70, p = 0.045) and reduced salivary flow (OR = 21.00, p = 0.013) were associated to body weight loss at T1. Taste changes significantly reduced the quality of life at T1, compared with T0. CONCLUSIONS: Frequency of hypogeusia was high in the neutropenia period of the HCT. None of the taste changes was determined by oral mucositis, tongue depapillation, or reduced salivary flow, but melphalan conditioning reduced the bitter taste sensation. Loss of body weight and poor quality of life were associated with taste changes and reduced salivary flow. Further studies are necessary to elucidate this association and the risk factors for taste changes in HCT.
PURPOSE: The aim of this study was to characterize the taste changes and taste bud atrophy observed in the period of neutropenia of HCT and to determine the influence of transplantation toxicity on these changes. METHODS: Autologous and allogeneic HCT patients (n = 51) were selected to perform taste acuity tests prior to conditioning (T0) and during neutropenia (T1). The frequency and time duration of oral mucositis, presence of tongue depapillation, and salivary flow rate were also evaluated. Quality of life was assessed using specific questionnaires. RESULTS: We observed a significant increase in hypogeusia (66.6%, p = 0.001) and dysgeusia (21.4%, p = 0.013) at T1, compared with T0. Bitter taste was the most altered, mainly when the patient underwent conditioning with melphalan (OR = 4.47, p = 0.049). Prolonged oral mucositis (≥ 8 days) (OR = 5.62, p = 0.039) and autologous transplantation (OR = 4.08, p = 0.033) were predictive factors for tongue depapillation. Changes in sour taste (OR = 10.70, p = 0.045) and reduced salivary flow (OR = 21.00, p = 0.013) were associated to body weight loss at T1. Taste changes significantly reduced the quality of life at T1, compared with T0. CONCLUSIONS: Frequency of hypogeusia was high in the neutropenia period of the HCT. None of the taste changes was determined by oral mucositis, tongue depapillation, or reduced salivary flow, but melphalan conditioning reduced the bitter taste sensation. Loss of body weight and poor quality of life were associated with taste changes and reduced salivary flow. Further studies are necessary to elucidate this association and the risk factors for taste changes in HCT.
Authors: Allan J Hovan; P Michele Williams; Peter Stevenson-Moore; Yula B Wahlin; Kirsten E O Ohrn; Linda S Elting; Fred K L Spijkervet; Michael T Brennan Journal: Support Care Cancer Date: 2010-05-22 Impact factor: 3.603
Authors: Rania Abasaeed; Susan E Coldwell; Michele E Lloid; Sohaib H Soliman; Paula C Macris; Mark M Schubert Journal: Support Care Cancer Date: 2018-04-27 Impact factor: 3.603
Authors: Harriët Jager-Wittenaar; Pieter U Dijkstra; Arjan Vissink; Bernard F A M van der Laan; Rob P van Oort; Jan L N Roodenburg Journal: Support Care Cancer Date: 2007-02-03 Impact factor: 3.603
Authors: Fernanda de Paula Eduardo; Leticia Mello Bezinelli; Marcella Ferreira Gobbi; Andrea Z Pereira; Cristina Vogel; Nelson Hamerschlak; Luciana Corrêa Journal: Nutr Cancer Date: 2017-12-26 Impact factor: 2.900
Authors: Jennifer Cohen; David G Laing; Fiona J Wilkes; Ada Chan; Melissa Gabriel; Richard J Cohn Journal: Appetite Date: 2014-01-08 Impact factor: 3.868
Authors: Jose Guilherme Vartanian; Andre Lopes Carvalho; Bevan Yueh; Cristina Lemos B Furia; Julia Toyota; Jennifer A McDowell; Ernest A Weymuller; Luiz Paulo Kowalski Journal: Head Neck Date: 2006-12 Impact factor: 3.147
Authors: P Schalk; M Kohl; H J Herrmann; R Schwappacher; M E Rimmele; A Buettner; J Siebler; M F Neurath; Y Zopf Journal: Support Care Cancer Date: 2017-09-25 Impact factor: 3.603