Linda Juel Ahrenfeldt1, Sören Möller2,3, Mikael Thinggaard4,5, Kaare Christensen4,5,6,7, Rune Lindahl-Jacobsen4. 1. Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9B, 5000, Odense C, Denmark. lahrenfeldt@health.sdu.dk. 2. OPEN - Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark. 3. Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 4. Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9B, 5000, Odense C, Denmark. 5. Danish Aging Research Center, University of Southern Denmark, Odense, Denmark. 6. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark. 7. Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Abstract
OBJECTIVES: To examine sex differences in prevalent comorbidity and frailty across age and European regions. METHODS: This is a cross-sectional study based on 113,299 Europeans aged 50+ participating in the Survey of Health, Ageing and Retirement in Europe from 2004-2005 to 2015. Sex differences in the Comorbidity Index and the Frailty Phenotype were investigated using ordinal logistic regressions. RESULTS: European women had generally higher odds of prevalent comorbidity (OR 1.11, 95% CI 1.07-1.15) and frailty (OR 1.56, 95% CI 1.51-1.62). Sex differences increased with advancing age. No overall sex difference in comorbidity was found in Western Europe, but women had more comorbidity than men in Eastern (OR 1.30, 95% CI 1.18-1.44), Southern (OR 1.23, 95% CI 1.15-1.30), and Northern (OR 1.08, 95% CI 1.01-1.16) Europe. Women were frailer than men in all regions, with the largest sex difference in Southern Europe (OR 1.84, 95% CI 1.72-1.96). CONCLUSIONS: European women are frailer and have slightly more comorbidity than European men lending support for the male-female health survival paradox.
OBJECTIVES: To examine sex differences in prevalent comorbidity and frailty across age and European regions. METHODS: This is a cross-sectional study based on 113,299 Europeans aged 50+ participating in the Survey of Health, Ageing and Retirement in Europe from 2004-2005 to 2015. Sex differences in the Comorbidity Index and the Frailty Phenotype were investigated using ordinal logistic regressions. RESULTS: European women had generally higher odds of prevalent comorbidity (OR 1.11, 95% CI 1.07-1.15) and frailty (OR 1.56, 95% CI 1.51-1.62). Sex differences increased with advancing age. No overall sex difference in comorbidity was found in Western Europe, but women had more comorbidity than men in Eastern (OR 1.30, 95% CI 1.18-1.44), Southern (OR 1.23, 95% CI 1.15-1.30), and Northern (OR 1.08, 95% CI 1.01-1.16) Europe. Women were frailer than men in all regions, with the largest sex difference in Southern Europe (OR 1.84, 95% CI 1.72-1.96). CONCLUSIONS: European women are frailer and have slightly more comorbidity than European men lending support for the male-female health survival paradox.
Entities:
Keywords:
Comorbidity; Europe; Frailty; SHARE; Sex differences
Authors: Yuji Okura; Lynn H Urban; Douglas W Mahoney; Steven J Jacobsen; Richard J Rodeheffer Journal: J Clin Epidemiol Date: 2004-10 Impact factor: 6.437
Authors: Carol H Gold; Bo Malmberg; Gerald E McClearn; Nancy L Pedersen; Stig Berg Journal: J Gerontol B Psychol Sci Soc Sci Date: 2002-05 Impact factor: 4.077
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: Linda Juel Ahrenfeldt; Jacob Krabbe Pedersen; Mikael Thinggaard; Kaare Christensen; Rune Lindahl-Jacobsen Journal: J Epidemiol Community Health Date: 2019-12-16 Impact factor: 3.710
Authors: Erin Hessey; Carmel Montgomery; Danny J Zuege; Darryl Rolfson; Henry T Stelfox; Kirsten M Fiest; Sean M Bagshaw Journal: J Intensive Care Date: 2020-09-29
Authors: Margarita Posso; Mercè Comas; Marta Román; Laia Domingo; Javier Louro; Cristina González; María Sala; Albert Anglès; Isabel Cirera; Francesc Cots; Víctor-Manuel Frías; Joaquim Gea; Robert Güerri-Fernández; Joan Ramon Masclans; Xavier Noguès; Olga Vázquez; Judith Villar-García; Juan Pablo Horcajada; Julio Pascual; Xavier Castells Journal: Arch Bronconeumol (Engl Ed) Date: 2020-11-11 Impact factor: 4.872
Authors: Margarita Posso; Mercè Comas; Marta Román; Laia Domingo; Javier Louro; Cristina González; María Sala; Albert Anglès; Isabel Cirera; Francesc Cots; Víctor-Manuel Frías; Joaquim Gea; Robert Güerri-Fernández; Joan Ramon Masclans; Xavier Noguès; Olga Vázquez; Judith Villar-García; Juan Pablo Horcajada; Julio Pascual; Xavier Castells Journal: Arch Bronconeumol (Engl Ed) Date: 2020-07-16 Impact factor: 4.872