Pillararenes as macrocyclic hosts: a rising star in metal ion separation.

Pillararenes are macrocyclic oligomers of alkoxybenzene akin to calixarenes but tethered at the 2,5-positions via methylene bridges. Benefiting from their unique pillar-shaped architecture favorable for diverse functionalization and versatile host-guest properties, pillararenes decorated with chelating groups worked excellently as supporting platforms to construct extractants or adsorbents for metal ion separation. This feature article provides a detailed summary of pillararenes in Ln/An separation by liquid-liquid extraction and heavy metal separation by solid-liquid extraction. The preorganization effect of the rigid pillararene framework has a profound impact on the extraction of metal ions, and a unique extraction mechanism is observed when employing ionic liquids as solvents. The rich host-guest chemistry of pillararenes enables construction of a wide variety of supramolecular materials as metal ion adsorbents. We also discuss the differences between pillararenes and several well-known macrocycles, with a focus on the metal-ligand coordination and its influencing factors. We hope this review will provide useful information and unleash new opportunities in this field.