| Literature DB >> 31235932 |
Cheryl E G Leyns1,2,3, Maud Gratuze1,2,3, Sneha Narasimhan4, Nimansha Jain1,2,3, Lauren J Koscal1,2,3, Hong Jiang1,2,3, Melissa Manis1,2,3, Marco Colonna2,3,5, Virginia M Y Lee4, Jason D Ulrich6,7,8, David M Holtzman9,10,11.
Abstract
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show that germline knockout of Trem2 or the TREM2R47H variant reduces microgliosis around amyloid-β plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting the development of peri-plaque tau pathologies.Entities:
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Year: 2019 PMID： 31235932 PMCID： PMC6660358 DOI： 10.1038/s41593-019-0433-0
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884