Literature DB >> 3123562

Detection of a soluble form of the receptor for interleukin 2 in the serum of patients with hairy cell leukaemia.

M Chilosi1, G Pizzolo, G Semenzato, G L Cetto.   

Abstract

The sera of patients with hairy cell leukaemia (HCL) contain a factor which inhibits the binding of anti-IL-2R antibody to its target (activated T lymphocytes). The presence of this factor, which probably corresponds to the soluble form of IL-2R (sIL-2R), can be easily detected using a simple immunocytochemical inhibition assay. In a series of patients with chronic lymphoproliferative diseases the presence of sIL-2R appeared to be specific for HCL, using the sensitivity of our test, since it could not be detected in sera from normal subjects and patients with B-cell lymphocytic leukaemia or Hodgkin's disease. Thus it might be used as an additional tool for characterizing HCL patients.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3123562     DOI： 10.1177/172460088600100208

Source DB:  PubMed          Journal:  Int J Biol Markers        ISSN： 0393-6155            Impact factor:   3.248


  5 in total

1.  Membrane-bound and soluble IL-2 receptors (p55 and p75 chains) on peripheral blood mononuclear cells from patients with solid malignancies.

Authors:  G Mantovani; A Macciò; G Astara; L Contini; S Esu; S Littera; V Arangino; P Lai; E Proto; G Pusceddu
Journal:  Cell Biophys       Date:  1993 Jan-Jun

2.  Membrane-bound/soluble IL-2 receptor (IL-2R) and levels of IL-1 alpha, IL-2, and IL-6 in the serum and in the PBMC culture supernatants from 17 patients with hematological malignancies.

Authors:  G Mantovani; A Macciò; P Lai; M Ghiani; E Turnu; G S Del Giacco
Journal:  Cell Biophys       Date:  1995-08

3.  Serum levels of soluble interleukin-2 receptors and their relation to lymphocyte subpopulations in patients with metastatic solid tumours.

Authors:  P Lissoni; S Barni; R Rescaldani; F Rovelli; G Tancini
Journal:  Br J Cancer       Date:  1989-10       Impact factor: 7.640

4.  Soluble interleukin-2 receptors in the serum of patients with Hodgkin's disease.

Authors:  G Pizzolo; M Chilosi; F Vinante; F Dazzi; M Lestani; G Perona; F Benedetti; G Todeschini; C Vincenzi; L Trentin
Journal:  Br J Cancer       Date:  1987-04       Impact factor: 7.640

5.  Serum soluble interleukin-2 receptor levels in patients with adult T-cell leukemia and human T-cell leukemia/lymphoma virus type-I seropositive healthy carriers.

Authors:  T Motoi; T Uchiyama; H Uchino; R Ueda; K Araki
Journal:  Jpn J Cancer Res       Date:  1988-05
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.