Nadia Russolillo1, Elisa Sperti2, Serena Langella3, Francesca Menonna3, Andrea Allieta3, Massimo Di Maio4, Alessandro Ferrero3. 1. Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy. Electronic address: nrussolillo@mauriziano.it. 2. Department of Oncology, Mauriziano Hospital, Turin, Italy. 3. Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy. 4. Department of Oncology, Mauriziano Hospital, Turin, Italy; Department of Oncology, University of Turin, Turin, Italy.
Abstract
BACKGROUND: Several studies have described a worse prognosis for right-sided colon cancer compared to left-sided. The aim of this study was to compare patterns of recurrence and survival following resection of liver metastases (LM) from right-sided (RS) versus left-sided (LS) colon cancer. METHODS: Patients undergoing resection for colon cancer LM between 2000 and 2017 were analyzed. Rectal cancer, multiple primaries and unknown location were excluded. RESULTS: Out of 995 patients, 686 fulfilled inclusion criteria (RS-LM = 322, LS-LM = 364). RS colon cancer had higher prevalence of metastatic lymph nodes (67.4% vs. 57.1%, P = 0.008). RS-LM were more often mucinous (16.8% vs. 8.5%, P = 0.001) and G3 (58.3% vs. 48.9%, P = 0.014). 451 (65.7%) patients experienced recurrence (RS-LM 68.9% vs. LS-LM 62.9%). In RS-LM group, recurrence was more often encephalic (2.3% vs. 0%, P = 0.029) and at multiple sites (34.2% vs. 23.5%, P = 0.012). The rate of re-resection was lower in RS-LM patients (27.9% vs. 37.5%, P = 0.024). Multivariate analysis showed RS-LM to have worse 5-year overall (35.8% vs. 51.2%, P = 0.002) and disease-free survival (26% vs. 43.6%, P = 0.002). CONCLUSIONS: RS-LM is associated with worse survival and aggressive recurrences, with lower chance of re-resection.
BACKGROUND: Several studies have described a worse prognosis for right-sided colon cancer compared to left-sided. The aim of this study was to compare patterns of recurrence and survival following resection of liver metastases (LM) from right-sided (RS) versus left-sided (LS) colon cancer. METHODS:Patients undergoing resection for colon cancer LM between 2000 and 2017 were analyzed. Rectal cancer, multiple primaries and unknown location were excluded. RESULTS: Out of 995 patients, 686 fulfilled inclusion criteria (RS-LM = 322, LS-LM = 364). RS colon cancer had higher prevalence of metastatic lymph nodes (67.4% vs. 57.1%, P = 0.008). RS-LM were more often mucinous (16.8% vs. 8.5%, P = 0.001) and G3 (58.3% vs. 48.9%, P = 0.014). 451 (65.7%) patients experienced recurrence (RS-LM 68.9% vs. LS-LM 62.9%). In RS-LM group, recurrence was more often encephalic (2.3% vs. 0%, P = 0.029) and at multiple sites (34.2% vs. 23.5%, P = 0.012). The rate of re-resection was lower in RS-LM patients (27.9% vs. 37.5%, P = 0.024). Multivariate analysis showed RS-LM to have worse 5-year overall (35.8% vs. 51.2%, P = 0.002) and disease-free survival (26% vs. 43.6%, P = 0.002). CONCLUSIONS: RS-LM is associated with worse survival and aggressive recurrences, with lower chance of re-resection.
Authors: Aditya Borakati; Farid Froghi; Alysha Shetye; Giuseppe K Fusai; Brian R Davidson; Reza Mirnezami Journal: World J Surg Date: 2022-03-24 Impact factor: 3.282
Authors: Ingrid Garajova; Rita Balsano; Chiara Tommasi; Raffaele Dalla Valle; Giuseppe Pedrazzi; Matteo Ravaioli; Andrea Spallanzani; Francesco Leonardi; Chiara Santini; Francesco Caputo; Mattia Riefolo; Mario Giuffrida; Fabio Gelsomino Journal: Acta Biomed Date: 2020-12-01