| Literature DB >> 31234652 |
Deepika Kandilya1, Silambarasan Maskomani1, Sukanya Shyamasundar1, Paul Anantharajah Tambyah2, Chan Shiao Yng3, Regina Ching Hua Lee4, Manoor Prakash Hande5, Karthik Mallilankaraman5, Justin Jang Hann Chu4, S Thameem Dheen1.
Abstract
Aim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly.Entities:
Keywords: DNA methylation; Hippo signaling; RASSF1; YAP/TAZ; Zika virus; human neural progenitor cells; microcephaly; stemness and differentiation
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Year: 2019 PMID： 31234652 DOI： 10.2217/epi-2018-0180
Source DB: PubMed Journal: Epigenomics ISSN： 1750-192X Impact factor: 4.778