Bjørn Andresen1, Agnese De Carli2, Monica Fumagalli2,3, Martina Giovannella4, Turgut Durduran4, Udo Michael Weigel5, Davide Contini6, Lorenzo Spinelli7, Alessandro Torricelli6,7, Gorm Greisen8. 1. Department of Neonatology, Rigshospitalet and Copenhagen University, Copenhagen, Denmark. 2. NICU Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 3. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. 4. ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Barcelona, Spain. 5. HemoPhotonics S.L. Castelldefels, Barcelona, Spain. 6. Politecnico di Milano-Dipartimento di Fisica, Milan, Italy. 7. Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Milan, Italy. 8. Department of Neonatology, Rigshospitalet and Copenhagen University, Copenhagen, Denmark. gorm.greisen@regionh.dk.
Abstract
BACKGROUND: The BabyLux device is a prototype optical neuro-monitor of cerebral oxygenation and blood flow for neonatology integrating time-resolved reflectance spectroscopy and diffuse correlation spectroscopy. METHODS: Here we report the variability of six consecutive 30 s measurements performed in 27 healthy term infants at rest. Poor data quality excluded four infants. RESULTS: Mean cerebral oxygenation was 59.6 ± 8.0%, with intra-subject standard deviation of 3.4%, that is, coefficient of variation (CV) of 5.7%. The inter-subject CV was 13.5%. Mean blood flow index was 2.7 × 10-8 ± 1.56 × 10-8 (cm2/s), with intra-subject CV of 27% and inter-subject CV of 56%. The variability in blood flow index was not reduced by the use of individual measures of tissue scattering, nor accompanied by a parallel variability in cerebral oxygenation. CONCLUSION: The intra-subject variability for cerebral oxygenation variability was improved compared to spatially resolved spectroscopy devices, while for the blood flow index it was comparable to that of other modalities for estimating cerebral blood flow in newborn infants. Most importantly, the simultaneous measurement of oxygenation and flow allows for interpretation of the high inter-subject variability of cerebral blood flow as being due to error of measurement rather than to physiological instability.
BACKGROUND: The BabyLux device is a prototype optical neuro-monitor of cerebral oxygenation and blood flow for neonatology integrating time-resolved reflectance spectroscopy and diffuse correlation spectroscopy. METHODS: Here we report the variability of six consecutive 30 s measurements performed in 27 healthy term infants at rest. Poor data quality excluded four infants. RESULTS: Mean cerebral oxygenation was 59.6 ± 8.0%, with intra-subject standard deviation of 3.4%, that is, coefficient of variation (CV) of 5.7%. The inter-subject CV was 13.5%. Mean blood flow index was 2.7 × 10-8 ± 1.56 × 10-8 (cm2/s), with intra-subject CV of 27% and inter-subject CV of 56%. The variability in blood flow index was not reduced by the use of individual measures of tissue scattering, nor accompanied by a parallel variability in cerebral oxygenation. CONCLUSION: The intra-subject variability for cerebral oxygenation variability was improved compared to spatially resolved spectroscopy devices, while for the blood flow index it was comparable to that of other modalities for estimating cerebral blood flow in newborn infants. Most importantly, the simultaneous measurement of oxygenation and flow allows for interpretation of the high inter-subject variability of cerebral blood flow as being due to error of measurement rather than to physiological instability.
Authors: Lorenzo Cortese; Giuseppe Lo Presti; Marco Pagliazzi; Davide Contini; Alberto Dalla Mora; Hamid Dehghani; Fabio Ferri; Jonas B Fischer; Martina Giovannella; Fabrizio Martelli; Udo M Weigel; Stanislaw Wojtkiewicz; Marta Zanoletti; Turgut Durduran Journal: Biomed Opt Express Date: 2021-05-11 Impact factor: 3.732
Authors: Leah I Elizondo; Eric L Vu; Kathleen K Kibler; Danielle R Rios; R Blaine Easley; Dean Andropoulos; Sebastian Acosta; Craig Rusin; Kenneth Brady; Christopher J Rhee Journal: Acta Neurochir Suppl Date: 2021
Authors: Ajay Rajaram; Daniel Milej; Marianne Suwalski; Lilian Kebaya; Matthew Kewin; Lawrence Yip; Sandrine de Ribaupierre; Victor Han; Mamadou Diop; Soume Bhattacharya; Keith St Lawrence Journal: Sci Rep Date: 2022-01-07 Impact factor: 4.379