Literature DB >> 31233122

A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis.

Raman Verma1, Benjamin M C Swift2, Wade Handley-Hartill3, Joanne K Lee1, Gerrit Woltmann4, Catherine E D Rees3, Pranabashis Haldar1.   

Abstract

The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  bacteriophage; bacteremia; blood; human tuberculosis

Mesh：

Year:  2020        PMID： 31233122     DOI： 10.1093/cid/ciz548

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  6 in total

1.  Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study.

Authors:  Mulugeta Belay; Begna Tulu; Sidra Younis; David A Jolliffe; Dawit Tayachew; Hana Manwandu; Tenagnework Abozen; Emawayish A Tirfie; Metasebia Tegegn; Aboma Zewude; Sally Forrest; Jonathan Mayito; Jim F Huggett; Gerwyn M Jones; Denise M O'Sullivan; Henny M Martineau; Mahdad Noursadeghi; Aneesh Chandran; Kathryn A Harris; Vlad Nikolayevskyy; Julie Demaret; Stefan Berg; Martin Vordermeier; Taye T Balcha; Abraham Aseffa; Gobena Ameni; Markos Abebe; Stephen T Reece; Adrian R Martineau
Journal:  Lancet Microbe       Date:  2021-06

Review 2.  Phage Amplification Assay for Detection of Mycobacterial Infection: A Review.

Authors:  Monika Beinhauerova; Iva Slana
Journal:  Microorganisms       Date:  2021-01-23

Review 3.  The definition of tuberculosis infection based on the spectrum of tuberculosis disease.

Authors:  Giovanni Battista Migliori; Catherine W M Ong; Linda Petrone; Lia D'Ambrosio; Rosella Centis; Delia Goletti
Journal:  Breathe (Sheff)       Date:  2021-09

4.  The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne's disease-infected animals.

Authors:  Benjamin M C Swift; Nathan Meade; Elsa Sandoval Barron; Malcolm Bennett; Tania Perehenic; Valerie Hughes; Karen Stevenson; Catherine E D Rees
Journal:  Microb Biotechnol       Date:  2019-12-03       Impact factor: 5.813

5.  Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study.

Authors:  Carolin T Turner; Rishi K Gupta; Evdokia Tsaliki; Jennifer K Roe; Prasenjit Mondal; Georgina R Nyawo; Zaida Palmer; Robert F Miller; Byron Wp Reeve; Grant Theron; Mahdad Noursadeghi
Journal:  Lancet Respir Med       Date:  2020-03-13       Impact factor: 30.700

6.  Latent Tuberculosis Infection-associated Immunodiagnostic Test Responses as Biomarkers of Incipient Tuberculosis: Fruitful or Futile?

Authors:  Keertan Dheda; Malika Davids
Journal:  Am J Respir Crit Care Med       Date:  2020-04-15       Impact factor: 21.405
  6 in total

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