Literature DB >> 3123274

Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor.

A Hepburn1, D Demolle, J m Boeynaems, W Fiers, J E Dumont.   

Abstract

Tumor necrosis factor (TNF) has been shown to induce the phosphorylation of a 27 kDa protein in a time- and concentration-dependent manner in HeLa D98/AH2, ME 180 and bovine aortic endothelial cells. This phosphorylation could be reproduced by the calcium ionophore, A23187. However, this phosphorylation was not observed in L929 cells, for which TNF is highly cytotoxic, suggesting that it might play a role in actions of TNF other than the induction of cell death.

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Year:  1988        PMID： 3123274     DOI： 10.1016/0014-5793(88)80892-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells.

Authors:  M W Marino; L M Pfeffer; P T Guidon; D B Donner
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  Effects of antisense hsp27 gene expression in osteosarcoma cells.

Authors:  P Rondeaux; S Horman; P Galand; N Mairesse
Journal:  In Vitro Cell Dev Biol Anim       Date:  1997-10       Impact factor: 2.416

3.  Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP.

Authors:  J Saklatvala; P Kaur; F Guesdon
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

4.  The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.

Authors:  D Stokoe; B Caudwell; P T Cohen; P Cohen
Journal:  Biochem J       Date:  1993-12-15       Impact factor: 3.857

5.  Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions.

Authors:  H Khalid; K Tsutsumi; H Yamashita; M Kishikawa; A Yasunaga; S Shibata
Journal:  Cell Mol Neurobiol       Date:  1995-04       Impact factor: 5.046

6.  Tumor necrosis factor induces the rapid phosphorylation of the mammalian heat shock protein hsp28.

Authors:  A P Arrigo
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

7.  The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

Authors:  R Beyaert; A Cuenda; W Vanden Berghe; S Plaisance; J C Lee; G Haegeman; P Cohen; W Fiers
Journal:  EMBO J       Date:  1996-04-15       Impact factor: 11.598

8.  Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

Authors:  B Robaye; R Mosselmans; W Fiers; J E Dumont; P Galand
Journal:  Am J Pathol       Date:  1991-02       Impact factor: 4.307

9.  Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

Authors:  Y Nophar; O Kemper; C Brakebusch; H Englemann; R Zwang; D Aderka; H Holtmann; D Wallach
Journal:  EMBO J       Date:  1990-10       Impact factor: 11.598

10.  Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.

Authors:  U Knauf; U Jakob; K Engel; J Buchner; M Gaestel
Journal:  EMBO J       Date:  1994-01-01       Impact factor: 11.598
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