Literature DB >> 3123086

Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis.

C E Elson1, T H Maltzman, J L Boston, M A Tanner, M N Gould.   

Abstract

d-Limonene was found to be effective in reducing the average number of rat mammary carcinomas that developed in 7,12-dimethylbenz[a]anthracene-treated rats when the terpene was fed during the initiation or during the promotion/progression stage of carcinogenesis. The time to the appearance of the first tumor was extended only when d-limonene was fed during the initiation stage. These effects could not be attributed to changes in mammary-relevant endocrine functions.

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Year:  1988        PMID： 3123086     DOI： 10.1093/carcin/9.2.331

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  25 in total

Review 1.  Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway.

Authors:  D W End
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

Review 2.  Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer.

Authors:  Huanjie Yang; Q Ping Dou
Journal:  Curr Drug Targets       Date:  2010-06       Impact factor: 3.465

Review 3.  Dietary factors modifying breast cancer risk and relation to time of intake.

Authors:  Airo Tsubura; Norihisa Uehara; Yasuhiko Kiyozuka; Nobuaki Shikata
Journal:  J Mammary Gland Biol Neoplasia       Date:  2005-01       Impact factor: 2.673

4.  Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention.

Authors:  Jessica A Miller; Kirk Pappan; Patricia A Thompson; Elizabeth J Want; Alexandros P Siskos; Hector C Keun; Jacob Wulff; Chengcheng Hu; Julie E Lang; H-H Sherry Chow
Journal:  Cancer Prev Res (Phila)       Date:  2014-11-11

5.  Safety and Feasibility of Topical Application of Limonene as a Massage Oil to the Breast.

Authors:  Jessica A Miller; Patricia A Thompson; Iman A Hakim; Ana Maria Lopez; Cynthia A Thomson; Wade Chew; Chiu-Hsieh Hsu; H-H Sherry Chow
Journal:  J Cancer Ther       Date:  2012-10

6.  Limonene in expired lung air of patients with liver disease.

Authors:  M I Friedman; G Preti; R O Deems; L S Friedman; S J Munoz; W C Maddrey
Journal:  Dig Dis Sci       Date:  1994-08       Impact factor: 3.199

7.  Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene.

Authors:  J D Haag; M N Gould
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

8.  Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth.

Authors:  P L Crowell; S Lin; E Vedejs; M N Gould
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

9.  Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.

Authors:  Jessica A Miller; Julie E Lang; Michele Ley; Ray Nagle; Chiu-Hsieh Hsu; Patricia A Thompson; Catherine Cordova; Amy Waer; H-H Sherry Chow
Journal:  Cancer Prev Res (Phila)       Date:  2013-04-03

10.  Human metabolism of the experimental cancer therapeutic agent d-limonene.

Authors:  P L Crowell; C E Elson; H H Bailey; A Elegbede; J D Haag; M N Gould
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333
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