| Literature DB >> 31230730 |
Emma M Groarke1, Neal S Young2.
Abstract
In hematopoiesis, mature blood cells, granulocytes, erythrocytes, and megakaryocytes originate from hematopoietic stem cells. With age, changes in hematopoiesis may have clinical consequences: defective immune responses, cytopenias (most commonly anemia and lymphopenia), hematological malignancy, and effects mediated by hematopoietic cells in other organs. Clonal hematopoiesis is commonly seen with aging and has been associated with both blood concerns and atherosclerosis, but further study is required to determine a causative link. Published by Elsevier Inc.Entities:
Keywords: Anemia in the elderly; Clonal cytopenia of undetermined significance; Clonal hematopoiesis of indeterminate potential; Hematopoiesis
Mesh:
Year: 2019 PMID: 31230730 PMCID: PMC8131033 DOI: 10.1016/j.cger.2019.03.001
Source DB: PubMed Journal: Clin Geriatr Med ISSN: 0749-0690 Impact factor: 3.076