| Literature DB >> 31230637 |
Lazaro E Aira1, Gudrun F Debes2.
Abstract
Melanoma is one of the deadliest cancers. In this issue, Kobayashi et al. (2019) demonstrate a novel role for tumor-infiltrating innate-like B1a B cells in promoting melanoma growth. IL-10+ (B1a) regulatory B cells accumulate selectively in melanomas, and enhance tumor growth through suppression of cytokine production by tumor-infiltrating CD8+ T cells and potentially additional IL-10-dependent mechanisms.Entities:
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Year: 2019 PMID： 31230637 DOI： 10.1016/j.jid.2019.03.1131
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551