Literature DB >> 3123013

Intracellular injection of a Ca2+ chelator inhibits spike repolarization in hippocampal neurons.

J F Storm1.   

Abstract

The Ca-dependence of spike repolarization and afterhyperpolarizations (AHPs) in Ca1 pyramidal cells, was tested with intracellular electrodes containing the Ca buffers EGTA or 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA). EGTA blocked only the slow AHP; but the fast-acting Ca chelator BAPTA also inhibited spike repolarization and the fast AHP. This supports the hypothesis that a fast Ca-activated'K-current contributes to spike repolarization.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3123013     DOI： 10.1016/0006-8993(87)91631-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  40 in total

1.  Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.

Authors:  H Hu; L R Shao; S Chavoshy; N Gu; M Trieb; R Behrens; P Laake; O Pongs; H G Knaus; O P Ottersen; J F Storm
Journal:  J Neurosci       Date:  2001-12-15       Impact factor: 6.167

2.  Differential control of three after-hyperpolarizations in rat hippocampal neurones by intracellular calcium buffering.

Authors:  A A Velumian; P L Carlen
Journal:  J Physiol       Date:  1999-05-15       Impact factor: 5.182

3.  Abbreviated action potential kinetics in a mouse model of potassium channel overexpression during hippocampal development.

Authors:  Stephen H Williams; Margaret L Sutherland
Journal:  Cell Mol Neurobiol       Date:  2004-06       Impact factor: 5.046

4.  Calculation of calcium dynamics from single wavelength fura-2 fluorescence recordings.

Authors:  I Vranesic; T Knöpfel
Journal:  Pflugers Arch       Date:  1991-03       Impact factor: 3.657

5.  Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels.

Authors:  Flora Jow; Zhi-Hao Zhang; David C Kopsco; Karen C Carroll; Kewei Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-14       Impact factor: 11.205

6.  Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons.

Authors:  Andreas Müller; Maria Kukley; Mischa Uebachs; Heinz Beck; Dirk Dietrich
Journal:  J Neurosci       Date:  2007-01-17       Impact factor: 6.167

7.  Ca2(+)-activated K+ current involvement in neuronal function revealed by in situ single-channel analysis in Helix neurones.

Authors:  M Gola; C Ducreux; H Chagneux
Journal:  J Physiol       Date:  1990-01       Impact factor: 5.182

8.  Blockade by local anaesthetics of the single Ca(2+)-activated K+ channel in rat hippocampal neurones.

Authors:  M Oda; A Yoshida; Y Ikemoto
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

9.  Muscarinic and beta-adrenergic depression of the slow Ca2(+)-activated potassium conductance in hippocampal CA3 pyramidal cells is not mediated by a reduction of depolarization-induced cytosolic Ca2+ transients.

Authors:  T Knöpfel; I Vranesic; B H Gähwiler; D A Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

Review 10.  Study of the anti-seizure effects of low-frequency stimulation following kindling (a review of the cellular mechanism related to the anti-seizure effects of low-frequency electrical stimulation).

Authors:  Zohreh Ghotbeddin; Mahyar Janahmadi; Ali Yadollahpour
Journal:  Neurol Sci       Date:  2016-08-26       Impact factor: 3.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.