Di Li1, Yan Li2. 1. Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: ld_director@qq.com. 2. Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: yanlitf1120@163.com.
Abstract
BACKGROUND: To study the association of α-carotenoid and β-carotenoid intakes from diet with depressive symptoms. METHODS: Cross-sectional study used data from the Study of Women's Health Across the Nation (SWAN). Linear regression, logistic regression and restricted cubic spline models were performed to examine the association α-carotenoid and β-carotenoid intakes with depression. RESULTS: A total of 2762 women aged 42-52 years were included in the present study. α-carotenoid and β-carotenoid intakes were inversely associated with CES-D scores in unadjusted and age-, race/ethnicity-, total family income- and sex hormone binding globulin-adjusted linear regression model. The multivariate adjusted regression coefficient with 95% confidence intervals (CIs) of CES-D score were -2.933 (-4.242, -1.623) and -0.153 (-0.282, -0.024) for α-carotenoid and β-carotenoid intakes. α-carotenoid and β-carotenoid intakes were inversely associated with high CES-D score (≥16) in unadjusted and age-, race/ethnicity-, total family income- and sex hormone binding globulin-adjusted logistic regression model. The multivariate adjusted Odds ratios (ORs) with 95% confidence intervals (CIs) of high CES-D score (≥16) were 0.718 (0.553-0.933) and 0.742 (0.571-0.964) for the highest versus lowest quartile of α-carotenoid and β-carotenoid intakes, respectively. However, association was not statistically significant between α-carotene and β-carotene intakes and society/work damage due to emotion problem. LIMITATIONS: This was a cross-sectional study, limiting causal inferences. Assessment of CES-D was based on a self-report scale. CONCLUSION: α-carotenoid and β-carotenoid intakes may be inversely associated with depressive symptoms in late midlife women.
BACKGROUND: To study the association of α-carotenoid and β-carotenoid intakes from diet with depressive symptoms. METHODS: Cross-sectional study used data from the Study of Women's Health Across the Nation (SWAN). Linear regression, logistic regression and restricted cubic spline models were performed to examine the association α-carotenoid and β-carotenoid intakes with depression. RESULTS: A total of 2762 women aged 42-52 years were included in the present study. α-carotenoid and β-carotenoid intakes were inversely associated with CES-D scores in unadjusted and age-, race/ethnicity-, total family income- and sex hormone binding globulin-adjusted linear regression model. The multivariate adjusted regression coefficient with 95% confidence intervals (CIs) of CES-D score were -2.933 (-4.242, -1.623) and -0.153 (-0.282, -0.024) for α-carotenoid and β-carotenoid intakes. α-carotenoid and β-carotenoid intakes were inversely associated with high CES-D score (≥16) in unadjusted and age-, race/ethnicity-, total family income- and sex hormone binding globulin-adjusted logistic regression model. The multivariate adjusted Odds ratios (ORs) with 95% confidence intervals (CIs) of high CES-D score (≥16) were 0.718 (0.553-0.933) and 0.742 (0.571-0.964) for the highest versus lowest quartile of α-carotenoid and β-carotenoid intakes, respectively. However, association was not statistically significant between α-carotene and β-carotene intakes and society/work damage due to emotion problem. LIMITATIONS: This was a cross-sectional study, limiting causal inferences. Assessment of CES-D was based on a self-report scale. CONCLUSION: α-carotenoid and β-carotenoid intakes may be inversely associated with depressive symptoms in late midlife women.