| Literature DB >> 31229874 |
Apeng Wang1, Kai Lv1, Linhu Li1, Hongtao Liu2, Zeyu Tao1, Bin Wang3, Mingliang Liu4, Chao Ma1, Xican Ma1, Bing Han1, Aoyu Wang1, Yu Lu5.
Abstract
A series of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides (IPAs), based on the structure of WZY02 discovered in our lab, were designed and synthesized as new anti-TB agents. Results reveal that many of them exhibit excellent in vitro inhibitory activity with low nanomolar MIC values against both drug-sensitive MTB strain H37Rv and drug-resistant clinical isolates. Compounds 15b and 15d display good safety and pharmacokinetic profiles, suggesting their promising potential to be lead compounds for future antitubercular drug discovery.Entities:
Keywords: Antimycobacterial activity; Design; Synthesis; imidazo[1,2-a]pyridine
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Year: 2019 PMID： 31229874 DOI： 10.1016/j.ejmech.2019.06.038
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514