David Hassanein Berro1, Solène Collet2, Jean-Marc Constans3, Louisa Barré4, Jean-Michel Derlon5, Evelyne Emery6, Jean-Sébastien Guillamo7, Samuel Valable2. 1. Department of Neurosurgery, University Hospital of Caen, avenue de la Côte de Nacre, 14000 Caen, France; Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France. Electronic address: dh@berro.net. 2. Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France. 3. Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France; Department of Neuroradiology, University Hospital of Caen, avenue de la Côte de Nacre, 14000 Caen, France. 4. Normandie University, UNICAEN, CEA, CNRS, ISTCT/LDM-TEP group, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France. 5. Department of Neurosurgery, University Hospital of Caen, avenue de la Côte de Nacre, 14000 Caen, France; Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France. 6. Department of Neurosurgery, University Hospital of Caen, avenue de la Côte de Nacre, 14000 Caen, France; Normandie University, UNICAEN, Inserm, Inserm UMR-S U919, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France. 7. Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, boulevard Henri Becquerel, 14000 Caen, France; Department of Neurology, University Hospital of Caen, avenue de la Côte de Nacre, 14000 Caen, France.
Abstract
BACKGROUND AND PURPOSE: Among principal MRI sequences used for a better pre-therapeutic characterization of glioblastoma (GBM), DWI-derived ADC is expected to be a good parameter for the evaluation of cellularity, due to restricted water diffusivity. We aimed here to compare ADC maps to 18FLT-PET, a proliferation tracer, in GBM cases. MATERIALS AND METHODS: Patients underwent 18FLT-PET, followed by multiparametric magnetic resonance imaging (MRI) just prior to surgery. We analysed in this study twenty GBM confirmed patients. The 5th percentile (5p) of the ADC values were thresholded to define the ADCmin ROI, while the 95th percentile (95p) of the SUV FLT values were used to define the FLTmax ROI. The statistical and spatial correlations between these two groups of ROIs were analyzed. RESULTS: We did not observe any significant correlations between ADCmin and FLTmax cut-off values (R2=0.0285), neither between ADCmin and FLTmax ROIs (mean Dice=0.09±0.12). Mean ADC values in the FLTmax defined ROI were significantly higher than the values in the ADCmin ROI (P<0.001). Mean FLT values in the FLTmax ROI were significantly higher than the values in the ADCmin ROI (P<0.001). CONCLUSIONS: When comparing ADC maps to 18FLT uptake, we did not observe significant anatomical overlap nor correlation, between the regions of low ADC and high FLT disabling to clearly link ADC values to cellular proliferation. The exact significance of ADC maps in GBM has yet to be elaborated.
BACKGROUND AND PURPOSE: Among principal MRI sequences used for a better pre-therapeutic characterization of glioblastoma (GBM), DWI-derived ADC is expected to be a good parameter for the evaluation of cellularity, due to restricted water diffusivity. We aimed here to compare ADC maps to 18FLT-PET, a proliferation tracer, in GBM cases. MATERIALS AND METHODS:Patients underwent 18FLT-PET, followed by multiparametric magnetic resonance imaging (MRI) just prior to surgery. We analysed in this study twenty GBM confirmed patients. The 5th percentile (5p) of the ADC values were thresholded to define the ADCmin ROI, while the 95th percentile (95p) of the SUV FLT values were used to define the FLTmax ROI. The statistical and spatial correlations between these two groups of ROIs were analyzed. RESULTS: We did not observe any significant correlations between ADCmin and FLTmax cut-off values (R2=0.0285), neither between ADCmin and FLTmax ROIs (mean Dice=0.09±0.12). Mean ADC values in the FLTmax defined ROI were significantly higher than the values in the ADCmin ROI (P<0.001). Mean FLT values in the FLTmax ROI were significantly higher than the values in the ADCmin ROI (P<0.001). CONCLUSIONS: When comparing ADC maps to 18FLT uptake, we did not observe significant anatomical overlap nor correlation, between the regions of low ADC and high FLT disabling to clearly link ADC values to cellular proliferation. The exact significance of ADC maps in GBM has yet to be elaborated.
Authors: Salem Boussida; Yvener François; Adrien Heintz; Zuzana Saidak; Stéphanie Dakpé; Alexandre Coutte; Bruno Chauffert; Bernard Devauchelle; Antoine Galmiche; Sylvie Testelin; Patrick Goudot; Jean-Marc Constans Journal: Front Oral Health Date: 2022-07-18