Jillian S Y Lau1, Shivani Bhatt2, Richard Streitberg3, Mellissa Bryant2, Tony M Korman4, Ian Woolley5. 1. Center for Inflammatory Diseases, Monash University, Clayton, Victoria, 3168, Australia; Monash Infectious Diseases, Monash Health, Clayton, Victoria, 3168, Australia. Electronic address: jillian.lau@monash.edu. 2. Monash Infectious Diseases, Monash Health, Clayton, Victoria, 3168, Australia. 3. Monash Pathology, Monash Health, Clayton, Victoria, 3168, Australia. 4. Center for Inflammatory Diseases, Monash University, Clayton, Victoria, 3168, Australia; Monash Infectious Diseases, Monash Health, Clayton, Victoria, 3168, Australia; Monash Pathology, Monash Health, Clayton, Victoria, 3168, Australia. 5. Center for Inflammatory Diseases, Monash University, Clayton, Victoria, 3168, Australia; Monash Infectious Diseases, Monash Health, Clayton, Victoria, 3168, Australia.
Abstract
BACKGROUND: Some patients receive long-term or life-long antibiotics for suppression of infections deemed otherwise incurable. Little is known about the consequences of this strategy. We aimed to explore patients' attitudes towards and knowledge concerning prolonged antibiotic therapy. METHODS: A cross-sectional cohort pilot study of outpatients on long-term antibiotics was performed. Surveys were conducted at our healthcare network in Victoria, Australia between April and December 2015. Microbiological screening for multi-resistant organisms (MRO) was also performed. RESULTS: Heterogeneity was noted in the prescribed antibiotics and documented indications, with rifampicin and fusidic acid for suppression of prosthetic joint infection the most common regimen and indication. 41% (12/29) of participants reported side-effects attributed to their antibiotics, but 72% (21/29) still declared complete adherence to their prescribed regimen. 76% (22/29) of participants stated that they would cease their long-term antibiotics based on medical advice. 19/29 (66%) participants consented to microbiological screening and 4 were found to be colonised with MROs. They had spent more days as an inpatient in the preceding 12 months than the screened participants who were not colonised. CONCLUSION: Participants in this study had a good understanding of their infection and the indications for their long-term antibiotic therapy, and were adherent to this therapy despite many experiencing side-effects attributed to their antibiotics. Patients who are prescribed life-long antibiotics can be carriers of multi-resistant organisms, but both the drivers of this resistance, and the broader impact of colonisation with MRO in this population is unclear. Crown
BACKGROUND: Some patients receive long-term or life-long antibiotics for suppression of infections deemed otherwise incurable. Little is known about the consequences of this strategy. We aimed to explore patients' attitudes towards and knowledge concerning prolonged antibiotic therapy. METHODS: A cross-sectional cohort pilot study of outpatients on long-term antibiotics was performed. Surveys were conducted at our healthcare network in Victoria, Australia between April and December 2015. Microbiological screening for multi-resistant organisms (MRO) was also performed. RESULTS: Heterogeneity was noted in the prescribed antibiotics and documented indications, with rifampicin and fusidic acid for suppression of prosthetic joint infection the most common regimen and indication. 41% (12/29) of participants reported side-effects attributed to their antibiotics, but 72% (21/29) still declared complete adherence to their prescribed regimen. 76% (22/29) of participants stated that they would cease their long-term antibiotics based on medical advice. 19/29 (66%) participants consented to microbiological screening and 4 were found to be colonised with MROs. They had spent more days as an inpatient in the preceding 12 months than the screened participants who were not colonised. CONCLUSION:Participants in this study had a good understanding of their infection and the indications for their long-term antibiotic therapy, and were adherent to this therapy despite many experiencing side-effects attributed to their antibiotics. Patients who are prescribed life-long antibiotics can be carriers of multi-resistant organisms, but both the drivers of this resistance, and the broader impact of colonisation with MRO in this population is unclear. Crown
Authors: Olivia Hawkins; Anna Mae Scott; Amy Montgomery; Bevan Nicholas; Judy Mullan; Antoine van Oijen; Chris Degeling Journal: PLoS One Date: 2022-01-14 Impact factor: 3.240
Authors: Nikoline Jensen; Henrik Elvang Jensen; Bent Aalbaek; Sophie Amalie Blirup-Plum; Sara M Soto; Virginio Cepas; Yuly López; Yaiza Gabasa; Ignacio Gutiérrez-Del-Río; Claudio J Villar; Felipe Lombó; María José Iglesias; Raquel Soengas; Fernando López Ortiz; Louise Kruse Jensen Journal: Front Microbiol Date: 2022-09-29 Impact factor: 6.064
Authors: Christopher Kiss; Declan Connoley; Kathryn Connelly; Kylie Horne; Tony Korman; Ian Woolley; Jillian S Y Lau Journal: Antibiotics (Basel) Date: 2022-01-05