Follicular Lymphoma: Redefining Prognosis, Current Treatment Options, and Unmet Needs.

Follicular lymphoma is the most common indolent lymphoma in the United States. In this review article, the authors discuss the different prognostic biomarkers available for follicular lymphoma. Treatment options, including observation, immunotherapy versus chemoimmunotherapy, in both the frontline and the relapse setting are also discussed in detail. Patients with follicular lymphoma with unmet needs include those with early relapse, with multiple relapses, and with histologic transformation. The treatment options for these patients are not well defined, and the authors discuss the available data for treating these patients.