| Literature DB >> 31228925 |
P A Abramicheva1, O V Smirnova2.
Abstract
The review describes functional and structural features of different isoforms of prolactin receptor, mechanisms of signaling pathway activation, and molecular messengers involved in the transmission and termination of signal from the prolactin receptor isoforms. Changes in the ratio between prolactin receptor isoforms, key mediators of prolactin signal transduction and termination in various organs and tissues, are analyzed. Special attention is given to the role of molecular mediators and the ratio between the isoforms in normal physiological functions and pathologies. Approaches for therapeutic correction of prolactin signaling impairments are discussed.Entities:
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Year: 2019 PMID: 31228925 DOI: 10.1134/S0006297919040011
Source DB: PubMed Journal: Biochemistry (Mosc) ISSN: 0006-2979 Impact factor: 2.487