Luigi Camera1, Filomena Pezzullo2, Angela Acampora2, Raffaele Liuzzi3, Antonio Rispo4, Olga Maria Nardone4, Gaetano Luglio5, Luigi Bucci5, Fabiana Castiglione4, Arturo Brunetti2. 1. Department of Advanced Biomedical Sciences - Section of Diagnostic Imaging, University "Federico II", Naples, Italy. Electronic address: camera@unina.it. 2. Department of Advanced Biomedical Sciences - Section of Diagnostic Imaging, University "Federico II", Naples, Italy. 3. Institute of Biostructures and Bioimaging, National Research Council, University "Federico II", Naples, Italy. 4. Department of Clinical Medicine and Surgery - Sections of Gastroenterology, University "Federico II", Naples, Italy. 5. Colo-rectal Surgery, University "Federico II", Naples, Italy.
Abstract
PURPOSE: To prospectively evaluate image quality and diagnostic efficacy of a low radiation-high contrast (LR-HC) CT Enterography (CTE) in active Inflammatory Bowel Disease (IBD). MATERIALS AND METHODS: Eighty-five (36M; 49F; 17-75 yrs) patients with active IBD underwent contrast-enhanced CTE and were stratified in two groups according to age (< or ≥45 yrs): Group A (N = 45; 32 ± 9 yrs; 58 ± 10 kg) and Group B (N = 40; 58 ± 10 yrs; 61 ± 13 kg). Each group received a different amount of radiation (Noise Index, NI) and non-ionic iodinated contrast media (LOCM) as follows: Group A (NI = 15; 2.5 ml/kg) and Group B (NI = 12.5; 2 ml/kg). Thyroid functional tests were performed in all patients of group A at 4-6 wks. Signal- and contrast-to-noise ratios were calculated for liver (L) and abdominal aorta (A). Statistical analysis was performed by Student's t- or Chi-square test for continuous and categorical data, respectively. RESULTS: No patient of Group A developed signs of thyrotoxicosis. SNRL, CNRL and diagnostic accuracy of CTE were 8.4 ± 1.7 vs 8.9 ± 2.1 (p = 0.256), 5.4 ± 1.5 vs 5.6 ± 1.7 (p = 0.486) and 91.1 vs 92.5% (p = 0.764) whereas the effective dose and the LOCM administered were 6.7 ± 2.2 vs 13.9 ± 6.0 mSv (p < 0.001) and 144 ± 25 vs 122 ± 25 ml (p < 0.001) for Group A and B, respectively. CONCLUSION: LR-HC CTE is a dose-effective protocol in the evaluation of active IBD in young patients.
PURPOSE: To prospectively evaluate image quality and diagnostic efficacy of a low radiation-high contrast (LR-HC) CT Enterography (CTE) in active Inflammatory Bowel Disease (IBD). MATERIALS AND METHODS: Eighty-five (36M; 49F; 17-75 yrs) patients with active IBD underwent contrast-enhanced CTE and were stratified in two groups according to age (< or ≥45 yrs): Group A (N = 45; 32 ± 9 yrs; 58 ± 10 kg) and Group B (N = 40; 58 ± 10 yrs; 61 ± 13 kg). Each group received a different amount of radiation (Noise Index, NI) and non-ionic iodinated contrast media (LOCM) as follows: Group A (NI = 15; 2.5 ml/kg) and Group B (NI = 12.5; 2 ml/kg). Thyroid functional tests were performed in all patients of group A at 4-6 wks. Signal- and contrast-to-noise ratios were calculated for liver (L) and abdominal aorta (A). Statistical analysis was performed by Student's t- or Chi-square test for continuous and categorical data, respectively. RESULTS: No patient of Group A developed signs of thyrotoxicosis. SNRL, CNRL and diagnostic accuracy of CTE were 8.4 ± 1.7 vs 8.9 ± 2.1 (p = 0.256), 5.4 ± 1.5 vs 5.6 ± 1.7 (p = 0.486) and 91.1 vs 92.5% (p = 0.764) whereas the effective dose and the LOCM administered were 6.7 ± 2.2 vs 13.9 ± 6.0 mSv (p < 0.001) and 144 ± 25 vs 122 ± 25 ml (p < 0.001) for Group A and B, respectively. CONCLUSION:LR-HC CTE is a dose-effective protocol in the evaluation of active IBD in young patients.
Authors: Olga Maria Nardone; Andrea Ponsiglione; Roberto de Sire; Giulio Calabrese; Raffaele Liuzzi; Anna Testa; Alessia Dalila Guarino; Oriana Olmo; Antonio Rispo; Luigi Camera; Fabiana Castiglione Journal: Nutrients Date: 2022-08-23 Impact factor: 6.706
Authors: Meng Qi Zheng; Qing Shi Zeng; Yong Quan Yu; Rui Ji; Yue Yue Li; Ming Ming Zhang; Yi Ning Sun; Li Xiang Li; Xiu Li Zuo; Xiao Yun Yang; Yan Qing Li Journal: J Dig Dis Date: 2020-01-15 Impact factor: 2.325