| Literature DB >> 31228614 |
Bhagyashri Kulkarni1, Prathibha Kirave1, Piyush Gondaliya1, Kavya Jash1, Alok Jain1, Rakesh K Tekade2, Kiran Kalia3.
Abstract
In the treatment of cancer, there are three significant limitations causing high mortality and recurrence rates among cancer patients. First, the escape of tumor cells from the immune system; second, the development of multi-drug resistance (MDR) to chemotherapeutic drugs; and, third, the noxious metastases of cancer cells. Exosomes are vesicular cargos involved in the transportation of miRNA, mRNA and proteins from one cell to another cell. This review details the current understanding of the exosomal transmission of miRNA and crosstalk with the downstream consequences, ultimately leading to the progression and metastasis of cancer. Further, this review also discusses how exosomal miRNA can provide promising novel targets for the treatment and detection of cancer.Entities:
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Year: 2019 PMID： 31228614 DOI： 10.1016/j.drudis.2019.06.010
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851