Somayeh Rostamian1, Sandra de Haan2, Jeroen van der Grond3, Mark A van Buchem3, Ian Ford4, J Wouter Jukema5, Behnam Sabayan6. 1. Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands. 2. Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. 3. Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands. 4. Robertson Centre for Biostatistics, University of Glasgow, United Kingdom. 5. Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands. 6. Northwestern University, Feinberg School of Medicine, Chicago, Ill. Electronic address: behnam.sabayan@northwestern.edu.
Abstract
BACKGROUND: Impairment in domain-specific cognitive function is associated with the increased risk of mortality. We prospectively evaluated the association of executive function and memory with the risk of long-term mortality in dementia-free older subjects. Moreover, we investigated the role of structural brain abnormalities in this association. METHODS: We included 547 dementia-free participants (mean age 78 years, 56.5% male) from the nested magnetic resonance imaging sub-study of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cox proportional hazard models were used to model 10-year risk of all-cause, cardiovascular, and noncardiovascular mortality in relation to performance in executive function and memory. Moreover, we evaluated the role of total brain parenchymal volume, cerebral blood flow, white matter hyperintensity, and the presence of microbleeds and infarcts in the link between cognitive function and mortality. RESULTS: In the multivariable model, lower performance in executive function was associated with greater risk of all-cause (hazard ratio [HR] 1.49; 95% confidence interval [CI], 1.31-1.70), cardiovascular (HR 1.69; 95% CI, 1.36-2.11), and noncardiovascular (HR 1.36; 95% CI, 1.15-1.62) mortality. Similarly, poorer performance in memory tests associated with higher risk of all-cause (HR 1.47; 95% CI, 1.29-1.68), cardiovascular (HR 1.45; 95% CI, 1.15-1.83), and noncardiovascular (HR 1.49; 95% CI, 1.27-1.76) mortality. The associations were similar in subjects with various levels of brain structural abnormalities and cerebral blood flow (all P for interaction ≫ .05). CONCLUSIONS: Poorer performance in both executive function and memory tests associates with all-cause, cardiovascular, and noncardiovascular mortality in elderly individuals. This association is independent of cardiovascular risk factors and diseases, brain structural abnormalities, and cerebral blood flow.
BACKGROUND: Impairment in domain-specific cognitive function is associated with the increased risk of mortality. We prospectively evaluated the association of executive function and memory with the risk of long-term mortality in dementia-free older subjects. Moreover, we investigated the role of structural brain abnormalities in this association. METHODS: We included 547 dementia-freeparticipants (mean age 78 years, 56.5% male) from the nested magnetic resonance imaging sub-study of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cox proportional hazard models were used to model 10-year risk of all-cause, cardiovascular, and noncardiovascular mortality in relation to performance in executive function and memory. Moreover, we evaluated the role of total brain parenchymal volume, cerebral blood flow, white matter hyperintensity, and the presence of microbleeds and infarcts in the link between cognitive function and mortality. RESULTS: In the multivariable model, lower performance in executive function was associated with greater risk of all-cause (hazard ratio [HR] 1.49; 95% confidence interval [CI], 1.31-1.70), cardiovascular (HR 1.69; 95% CI, 1.36-2.11), and noncardiovascular (HR 1.36; 95% CI, 1.15-1.62) mortality. Similarly, poorer performance in memory tests associated with higher risk of all-cause (HR 1.47; 95% CI, 1.29-1.68), cardiovascular (HR 1.45; 95% CI, 1.15-1.83), and noncardiovascular (HR 1.49; 95% CI, 1.27-1.76) mortality. The associations were similar in subjects with various levels of brain structural abnormalities and cerebral blood flow (all P for interaction ≫ .05). CONCLUSIONS: Poorer performance in both executive function and memory tests associates with all-cause, cardiovascular, and noncardiovascular mortality in elderly individuals. This association is independent of cardiovascular risk factors and diseases, brain structural abnormalities, and cerebral blood flow.
Authors: Dalia Luksiene; Laura Sapranaviciute-Zabazlajeva; Abdonas Tamosiunas; Ricardas Radisauskas; Martin Bobak Journal: BMC Public Health Date: 2021-04-24 Impact factor: 3.295
Authors: Somayeh Rostamian; Saskia le Cessie; Koen A Marijt; J Wouter Jukema; Simon P Mooijaart; Mark A van Buchem; Thorbald van Hall; Jacobijn Gussekloo; Stella Trompet Journal: PLoS One Date: 2022-01-07 Impact factor: 3.240