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Literature DB >> 31228261

STIM calcium sensing and conformational change.

Aparna Gudlur¹, Ana Eliza Zeraik^1,2, Nupura Hirve¹, Patrick G Hogan^1,3,4.

Abstract

The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: ORAI; STIM; calcium; conformational change; store depletion

Mesh：

Substances：

Year: 2019 PMID： 31228261 PMCID： PMC6925660 DOI： 10.1113/JP276524

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

47 in total

Review 1. Store-Operated Calcium Channels.

Authors: Murali Prakriya; Richard S Lewis
Journal: Physiol Rev Date: 2015-10 Impact factor: 37.312

2. STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels.

Authors: Maria A Spassova; Jonathan Soboloff; Li-Ping He; Wen Xu; Marie A Dziadek; Donald L Gill
Journal: Proc Natl Acad Sci U S A Date: 2006-03-06 Impact factor: 11.205

3. Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.

Authors: Zhengzheng Li; Jingze Lu; Pingyong Xu; Xiangyang Xie; Liangyi Chen; Tao Xu
Journal: J Biol Chem Date: 2007-08-16 Impact factor: 5.157

4. Intrinsic disorder mediates cooperative signal transduction in STIM1.

Authors: Yukio Furukawa; Shunsuke Teraguchi; Takahisa Ikegami; Onur Dagliyan; Lin Jin; Damien Hall; Nikolay V Dokholyan; Keiichi Namba; Shizuo Akira; Tomohiro Kurosaki; Yoshihiro Baba; Daron M Standley
Journal: J Mol Biol Date: 2014-03-17 Impact factor: 5.469

5. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

Authors: Shenyuan L Zhang; Ying Yu; Jack Roos; J Ashot Kozak; Thomas J Deerinck; Mark H Ellisman; Kenneth A Stauderman; Michael D Cahalan
Journal: Nature Date: 2005-10-06 Impact factor: 49.962

6. Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm.

Authors: Nupura Hirve; Vangipurapu Rajanikanth; Patrick G Hogan; Aparna Gudlur
Journal: Cell Rep Date: 2018-01-02 Impact factor: 9.423

7. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.

Authors: Peter B Stathopulos; Le Zheng; Guang-Yao Li; Michael J Plevin; Mitsuhiko Ikura
Journal: Cell Date: 2008-10-03 Impact factor: 41.582

8. A conserved, lipid-mediated sorting mechanism of yeast Ist2 and mammalian STIM proteins to the peripheral ER.

Authors: Ebru Ercan; Frank Momburg; Ulrike Engel; Koen Temmerman; Walter Nickel; Matthias Seedorf
Journal: Traffic Date: 2009-10-05 Impact factor: 6.215

9. Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating.

Authors: Jozsef Maléth; Seok Choi; Shmuel Muallem; Malini Ahuja
Journal: Nat Commun Date: 2014-12-17 Impact factor: 14.919

STIM calcium sensing and conformational change.

Review 1. Store-Operated Calcium Channels.

2. STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels.

3. Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.

4. Intrinsic disorder mediates cooperative signal transduction in STIM1.

5. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

6. Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm.

7. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.

8. A conserved, lipid-mediated sorting mechanism of yeast Ist2 and mammalian STIM proteins to the peripheral ER.

9. Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating.

10. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.

1. Mechanism of STIM activation.

Review 2. STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.

3. Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.

4. The store-operated Ca²⁺ entry complex comprises a small cluster of STIM1 associated with one Orai1 channel.

Review 5. STIM Proteins: An Ever-Expanding Family.

Review 6. The Important Role of Ion Transport System in Cervical Cancer.

7. Enforced tethering elongates the cortical endoplasmic reticulum and limits store-operated Ca2+ entry.

Review 8. STIM Proteins and Regulation of SOCE in ER-PM Junctions.