Yupeng Guan1, Gang Yu1, Guoren Wang1, Zhiming Bai2. 1. Department of Urology, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, No.43, Renmin Avenue, Meilan District, Haikou City, 570208, Hainan Province, China. 2. Department of Urology, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, No.43, Renmin Avenue, Meilan District, Haikou City, 570208, Hainan Province, China. hkbzm2018@aliyun.com.
Abstract
INTRODUCTION AND HYPOTHESIS: To explore the effect of urologic chronic pelvic pain syndrome (UCPPS) on female sexual function. METHODS: Database searches were conducted in PubMed, EMBASE, the Cochrane Library, and Google Scholar for published literature using the Female Sexual Function Index (FSFI) or reporting the prevalence of dyspareunia. Data extraction and quality evaluation were performed on the literature that met the inclusion criteria, and a meta-analysis was performed using STATA 12.0 and RevMan5.3 software to calculate the mean differences (MD) and odds ratios (OR) and their 95% confidence intervals (CI). RESULTS: A total of nine case-control studies enrolling 4965 subjects were investigated. The present meta-analysis results demonstrated a strong correlation between UCPPS and dyspareunia (OR = 11.27, 95% CI: 5.15-24.67, P < 0.00001). The UCPPS group had significantly lower scores in each domain of the FSFI compared with the healthy control group: total score (MD = -11.35, 95% CI: -14.54- - 8.16, P < 0.00001); desire (MD = -1.04, 95% CI: -1.20- - 0.88, P < 0.00001); arousal (MD = -1.78, 95% CI: -2.36- - 1.20, P < 0.00001); lubrication (MD = -2.11, 95% CI: -2.49- - 1.73, P < 0.00001); orgasm (MD = -1.50, 95% CI: -1.72- - 1.28, P < 0.00001); satisfaction (MD = -1.54, 95% CI: -1.97- - 1.12, P < 0.00001); pain (MD = -2.89, 95% CI: -3.63- - 2.14, P < 0.00001). CONCLUSIONS: UCPPS had a significantly negative effect on female sexual function, particularly in the lubrication, pain, and total score domains. In addition, UCPPS patients had a significantly higher risk of dyspareunia. Psychosocial variables may be a potential pathogenesis of female sexual dysfunction (FSD). Future well-designed research is called for to develop a comprehensive estimate of the association between UCPPS and FSD.
INTRODUCTION AND HYPOTHESIS: To explore the effect of urologic chronic pelvic pain syndrome (UCPPS) on female sexual function. METHODS: Database searches were conducted in PubMed, EMBASE, the Cochrane Library, and Google Scholar for published literature using the Female Sexual Function Index (FSFI) or reporting the prevalence of dyspareunia. Data extraction and quality evaluation were performed on the literature that met the inclusion criteria, and a meta-analysis was performed using STATA 12.0 and RevMan5.3 software to calculate the mean differences (MD) and odds ratios (OR) and their 95% confidence intervals (CI). RESULTS: A total of nine case-control studies enrolling 4965 subjects were investigated. The present meta-analysis results demonstrated a strong correlation between UCPPS and dyspareunia (OR = 11.27, 95% CI: 5.15-24.67, P < 0.00001). The UCPPS group had significantly lower scores in each domain of the FSFI compared with the healthy control group: total score (MD = -11.35, 95% CI: -14.54- - 8.16, P < 0.00001); desire (MD = -1.04, 95% CI: -1.20- - 0.88, P < 0.00001); arousal (MD = -1.78, 95% CI: -2.36- - 1.20, P < 0.00001); lubrication (MD = -2.11, 95% CI: -2.49- - 1.73, P < 0.00001); orgasm (MD = -1.50, 95% CI: -1.72- - 1.28, P < 0.00001); satisfaction (MD = -1.54, 95% CI: -1.97- - 1.12, P < 0.00001); pain (MD = -2.89, 95% CI: -3.63- - 2.14, P < 0.00001). CONCLUSIONS: UCPPS had a significantly negative effect on female sexual function, particularly in the lubrication, pain, and total score domains. In addition, UCPPS patients had a significantly higher risk of dyspareunia. Psychosocial variables may be a potential pathogenesis of female sexual dysfunction (FSD). Future well-designed research is called for to develop a comprehensive estimate of the association between UCPPS and FSD.
Entities:
Keywords:
Dyspareunia; Female Sexual Function Index; Female sexual dysfunction; Meta-analysis; Urologic chronic pelvic pain syndrome
Authors: Andrew Schrepf; Michael O'Donnell; Yi Luo; Catherine S Bradley; Karl Kreder; Susan Lutgendorf Journal: Pain Date: 2014-06-05 Impact factor: 6.961
Authors: D F Stroup; J A Berlin; S C Morton; I Olkin; G D Williamson; D Rennie; D Moher; B J Becker; T A Sipe; S B Thacker Journal: JAMA Date: 2000-04-19 Impact factor: 56.272
Authors: K T Zondervan; P L Yudkin; M P Vessey; C P Jenkinson; M G Dawes; D H Barlow; S H Kennedy Journal: Am J Obstet Gynecol Date: 2001-05 Impact factor: 8.661
Authors: Kenneth M Peters; Kim A Killinger; Donna J Carrico; Ibrahim A Ibrahim; Ananias C Diokno; Alessandra Graziottin Journal: Urology Date: 2007-09 Impact factor: 2.649
Authors: Joop P van de Merwe; Jørgen Nordling; Pierre Bouchelouche; Kirsten Bouchelouche; Mauro Cervigni; L Kurosch Daha; Suzy Elneil; Magnus Fall; Gero Hohlbrugger; Paul Irwin; Svend Mortensen; Arndt van Ophoven; John L Osborne; Ralph Peeker; Benedikte Richter; Claus Riedl; Jukka Sairanen; Martina Tinzl; Jean-Jacques Wyndaele Journal: Eur Urol Date: 2007-09-20 Impact factor: 20.096
Authors: J Quentin Clemens; Chris Mullins; John W Kusek; Ziya Kirkali; Emeran A Mayer; Larissa V Rodríguez; David J Klumpp; Anthony J Schaeffer; Karl J Kreder; Dedra Buchwald; Gerald L Andriole; M Scott Lucia; J Richard Landis; Daniel J Clauw Journal: BMC Urol Date: 2014-08-01 Impact factor: 2.264
Authors: Geetika Reichmann; Anna Beth Parlier-Ahmad; Lori Beck; Bhushan Thakkar; Meryl Alappattu; Jeff Boissoneault; Caitlin E Martin Journal: Front Pain Res (Lausanne) Date: 2022-01-11