Alexis Kahn1, Jean-Daniel Kün-Darbois2, Helios Bertin3, Pierre Corre3, Daniel Chappard4. 1. Department of Oral and Maxillofacial surgery, Chu d'Angers, Angers, Cedex, France; Department of Oral and Maxillofacial surgery, Chu de Nantes, Nantes, Cedex 1, France. 2. Department of Oral and Maxillofacial surgery, Chu d'Angers, Angers, Cedex, France; Groupe Etudes Remodelage Osseux et bioMatériaux, GEROM, UNIV Angers, SFR 42-08, IRIS-IBS Institut de Biologie en Santé, Chu d'Angers, Angers, Cedex, France. 3. Department of Oral and Maxillofacial surgery, Chu de Nantes, Nantes, Cedex 1, France. 4. Groupe Etudes Remodelage Osseux et bioMatériaux, GEROM, UNIV Angers, SFR 42-08, IRIS-IBS Institut de Biologie en Santé, Chu d'Angers, Angers, Cedex, France. Electronic address: Daniel.chappard@univ-angers.fr.
Abstract
OBJECTIVE: Botulinum toxin (BTX) is injected into masticatory muscles to treat various conditions. Animal studies have demonstrated bone loss at the condylar and alveolar regions of the mandible after BTX injection into masticatory muscles. The aim of the present study was to investigate mandibular bone changes in patients who received BTX injections in masticatory muscles. STUDY DESIGN: Twelve adult patients who received BTX injections into masticatory muscles were included in this study. Cone beam computed tomography (CBCT) was performed before and 12 months after the injection. The condylar and alveolar regions of the mandible were analyzed by using texture analysis of the CBCT images with the run length method. Condylar cortical thickness was measured, and 3-dimensional analysis of the mandible was also performed. Six patients who did not receive BTX injections were used as controls. RESULTS: A run length parameter (gray level nonuniformity) was found to be increased in condylar and alveolar bones. A significant cortical thinning was found at the anterior portion of the right condyle. Three-dimensional analysis showed significant changes in the condylar bone and at the digastric fossa. No changes in mandibular angles were found. CONCLUSIONS: This study identified mandibular bone changes in adult patients who received BTX injection into masticatory muscles.
OBJECTIVE: Botulinum toxin (BTX) is injected into masticatory muscles to treat various conditions. Animal studies have demonstrated bone loss at the condylar and alveolar regions of the mandible after BTX injection into masticatory muscles. The aim of the present study was to investigate mandibular bone changes in patients who received BTX injections in masticatory muscles. STUDY DESIGN: Twelve adult patients who received BTX injections into masticatory muscles were included in this study. Cone beam computed tomography (CBCT) was performed before and 12 months after the injection. The condylar and alveolar regions of the mandible were analyzed by using texture analysis of the CBCT images with the run length method. Condylar cortical thickness was measured, and 3-dimensional analysis of the mandible was also performed. Six patients who did not receive BTX injections were used as controls. RESULTS: A run length parameter (gray level nonuniformity) was found to be increased in condylar and alveolar bones. A significant cortical thinning was found at the anterior portion of the right condyle. Three-dimensional analysis showed significant changes in the condylar bone and at the digastric fossa. No changes in mandibular angles were found. CONCLUSIONS: This study identified mandibular bone changes in adult patients who received BTX injection into masticatory muscles.
Authors: Karen G Raphael; Malvin N Janal; Aditya Tadinada; Vivian Santiago; David A Sirois; Alan G Lurie Journal: J Oral Rehabil Date: 2020-09-19 Impact factor: 3.837