Literature DB >> 3122740

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.

P Suffys1, R Beyaert, F Van Roy, W Fiers.   

Abstract

The mechanism of tumour necrosis factor-mediated cytotoxicity was investigated by using various inhibitors of arachidonic acid metabolism. Phospholipase A2 inhibitors with different modes of action interfered with the cytotoxic action of TNF, whereas phospholipase C inhibitors did not. Neither cyclooxygenase nor lipoxygenase-blockers had a significant effect on TNF action. Experiments with scavengers of toxic oxygen radicals gave ambiguous results. The data obtained suggest the involvement of phospholipase A2 and arachidonic acid in the cytotoxic mechanism of TNF, but the exact role of these molecules is, however, still to be determined.

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Year:  1987        PMID： 3122740     DOI： 10.1016/0006-291x(87)90429-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

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Authors:  H Pfister; T Hennet; T W Jungi
Journal:  Immunology       Date:  1992-11       Impact factor: 7.397

2.  Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.

Authors:  R Beyaert; B Vanhaesebroeck; P Suffys; F Van Roy; W Fiers
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3.  Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain.

Authors:  V B O'Donnell; S Spycher; A Azzi
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

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Authors:  X Sun; M S Caplan; W Hsueh
Journal:  Gut       Date:  1994-02       Impact factor: 23.059

5.  Effects of n-3 and n-6 fatty acids on tumor necrosis factor cytotoxicity in WEHI fibrosarcoma cells.

Authors:  O L Brekke; T Espevik; T Bardal; K S Bjerve
Journal:  Lipids       Date:  1992-03       Impact factor: 1.880

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7.  Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolysis, increases the virulence of vaccinia virus in severe combined immunodeficient mice.

Authors:  J M Tufariello; S Cho; M S Horwitz
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

8.  Butylated hydroxyanisole inhibits tumor necrosis factor-induced cytotoxicity and arachidonic acid release.

Authors:  O L Brekke; T Espevik; K S Bjerve
Journal:  Lipids       Date:  1994-02       Impact factor: 1.880

9.  Cellular stress and glucocorticoid hormones protect L929 mouse fibroblasts from tumor necrosis factor alpha cytotoxicity.

Authors:  M C Pagliacci; G Migliorati; M Smacchia; F Grignani; C Riccardi; I Nicoletti
Journal:  J Endocrinol Invest       Date:  1993-09       Impact factor: 4.256

10.  Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines.

Authors:  D Eads; Rl Hansen; Ao Oyegunwa; Ce Cecil; Ca Culver; F Scholle; Itd Petty; Sm Laster
Journal:  J Inflamm (Lond)       Date:  2009-01-08       Impact factor: 4.981
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