Literature DB >> 31227344

SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.

Scott D Kuduk1, Angela M Lam2, Christine Espiritu2, Robert Vogel2, Vincent Lau2, Klaus Klumpp2, Osvaldo A Flores2, George D Hartman2.   

Abstract

The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly process has shown clinical efficacy in early clinical trials. Herein is described the SAR exploration of NVR 3-778, the first clinical compound in the sulfonyl carboxamide class.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Capsid modulator; Core protein; HBV; Sulfonamide

Year:  2019        PMID： 31227344     DOI： 10.1016/j.bmcl.2019.05.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators.

Authors:  Nicky Hwang; Haiqun Ban; Shuo Wu; Kelly McGuire; Ellen Hernandez; Junjun Chen; Qiong Zhao; Manasa Suresh; Benjamin Blass; Usha Viswanathan; John Kulp; Jinhong Chang; Jason Clement; Stephan Menne; Ju-Tao Guo; Yanming Du
Journal:  Bioorg Med Chem Lett       Date:  2021-12-31       Impact factor: 2.823

2.  Discovery of SHR5133, a Highly Potent and Novel HBV Capsid Assembly Modulator.

Authors:  Xin Li; Zhigao Zhang; Yang Chen; Bin Wang; Guimei Yang; Xiangbin Xu; Baihui Yechao; Dongdong Bai; Binqiang Feng; Yuchang Mao; Jun Feng; Chang Bai; Feng He; Weikang Tao
Journal:  ACS Med Chem Lett       Date:  2022-02-17       Impact factor: 4.345
  2 in total

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