Gabriela Batitucci1, Camila Fernanda Cunha Brandao2, Flávia Giolo De Carvalho3, Julio Sergio Marchini4, Karina Pfrimer5, Eduardo Ferrioli6, Fernando Queiroz Cunha7, Marcelo Papoti8, Sara Ivone Barros Morhy Terrazas9, Márcia Varella Morandi Junqueira-Franco10, Adelino Sanchez Ramos da Silva11, Ellen Cristini de Freitas12. 1. Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of São Paulo, Rod. Araraquara - Jau Km 1, Araraquara, SP, Brazil. Electronic address: gabibatitucci@gmail.com. 2. Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: camilafbrandao@hotmail.com. 3. School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: flaviagiolo@gmail.com. 4. Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: jsmarchi@fmrp.usp.br. 5. Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: karinapfrimer@hotmail.com. 6. Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: eferriol@fmrp.usp.br. 7. Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: fdqcunha@fmrp.usp.br. 8. School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: mpapoti@usp.br. 9. Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of São Paulo, Rod. Araraquara - Jau Km 1, Araraquara, SP, Brazil. Electronic address: saraterrazas@yahoo.com.br. 10. Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: mvmjf@hotmail.com. 11. School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: adelinosanchez@hotmail.com. 12. Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of São Paulo, Rod. Araraquara - Jau Km 1, Araraquara, SP, Brazil; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil. Electronic address: ellenfreitas@usp.br.
Abstract
BACKGROUND: Irisin is a myokine/adipokine that under stimulus of physical exercise is able to improve thermogenic capacity in adipose tissue. Likewise, taurine supplementation has demonstrated similar effects on energy metabolism. Therefore, we hypothesized that taurine supplementation combined with physical training may induce an increase in irisin concentrations, optimizing energy metabolism in obese individuals. OBJECTIVE: To evaluate if taurine supplementation associated with a high intensity physical training program increases irisin levels in obese women. METHODS: double-blind study with 22 obese women (BMI 32.4 ± 2.0 kg/m2, 36.6 ± 6.4 years and sedentary) who were randomly divided into two groups, control group (GC, n = 14), exercised and supplemented with placebo (3 g of starch), and taurine group (GTAU, n = 8), exercised and supplemented with taurine (3 g). The subjects performed high intensity physical training, Deep Water Running (DWR), for 8 weeks, 3 times/week, for 50 min per training session, at 70-85% maximum heart rate. Resting metabolic rate (RMR) was evaluated by indirect calorimetry, body composition by deuterium oxide, plasma taurine by HPLC, plasma irisin by Multiplex Kit, and food consumption by food records. The results were analyzed by an ANOVA two way repeated measures mixed model, with the Sidak post hoc (p < 0.05). RESULTS: No changes were observed in body composition. DWR increased RMR independent of supplementation (p < 0.001) and irisin levels (pg/mL) showed a significant difference only in the GTAU in 1 h after exercise (p < 0.001). CONCLUSION: DWR associated with taurine supplementation resulted in increased plasma irisin concentrations after physical training in obese adult women.
RCT Entities:
BACKGROUND:Irisin is a myokine/adipokine that under stimulus of physical exercise is able to improve thermogenic capacity in adipose tissue. Likewise, taurine supplementation has demonstrated similar effects on energy metabolism. Therefore, we hypothesized that taurine supplementation combined with physical training may induce an increase in irisin concentrations, optimizing energy metabolism in obese individuals. OBJECTIVE: To evaluate if taurine supplementation associated with a high intensity physical training program increases irisin levels in obesewomen. METHODS: double-blind study with 22 obesewomen (BMI 32.4 ± 2.0 kg/m2, 36.6 ± 6.4 years and sedentary) who were randomly divided into two groups, control group (GC, n = 14), exercised and supplemented with placebo (3 g of starch), and taurine group (GTAU, n = 8), exercised and supplemented with taurine (3 g). The subjects performed high intensity physical training, Deep Water Running (DWR), for 8 weeks, 3 times/week, for 50 min per training session, at 70-85% maximum heart rate. Resting metabolic rate (RMR) was evaluated by indirect calorimetry, body composition by deuterium oxide, plasma taurine by HPLC, plasma irisin by Multiplex Kit, and food consumption by food records. The results were analyzed by an ANOVA two way repeated measures mixed model, with the Sidak post hoc (p < 0.05). RESULTS: No changes were observed in body composition. DWR increased RMR independent of supplementation (p < 0.001) and irisin levels (pg/mL) showed a significant difference only in the GTAU in 1 h after exercise (p < 0.001). CONCLUSION: DWR associated with taurine supplementation resulted in increased plasma irisin concentrations after physical training in obese adult women.
Authors: Sun-Hong Baek; Ga-Ram Hong; Do-Kyum Min; Eun-Hee Kim; Sang-Kab Park Journal: Int J Environ Res Public Health Date: 2021-07-28 Impact factor: 4.614