Literature DB >> 31226273

Calcium Influx Guards Replication Forks against Exonuclease 1.

Antoine Simoneau1, Lee Zou2.   

Abstract

In this issue, Li et al. (2019) report a previously unknown Ca2+-CaMKK2-AMPK signaling cascade that protects stalled forks from degradation by phosphorylating and inhibiting the EXO1 nuclease, revealing a surprising role for Ca2+ influx in the maintenance of genomic stability.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Year:  2019        PMID: 31226273     DOI: 10.1016/j.molcel.2019.06.005

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  1 in total

1.  The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1.

Authors:  Iwona Hirschler-Laszkiewicz; Fernanda Festa; Suming Huang; George-Lucian Moldovan; Claudia Nicolae; Ashna Dhoonmoon; Lei Bao; Kerry Keefer; Shu-Jen Chen; Hong-Gang Wang; Joseph Y Cheung; Barbara A Miller
Journal:  Sci Rep       Date:  2022-04-15       Impact factor: 4.996

  1 in total

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