Teresa Mannarino1, Roberta Assante1, Carlo Ricciardi1, Emilia Zampella1, Carmela Nappi1, Valeria Gaudieri1, Ciro Gabriele Mainolfi1, Eugenio Di Vaia1, Mario Petretta2, Mario Cesarelli3, Alberto Cuocolo1, Wanda Acampa4,5. 1. Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy. 2. Department of Translational Medical Sciences, University Federico II, Naples, Italy. 3. Department of Electrical Engineering and Information Technology, University Federico II, Naples, Italy. 4. Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy. acampa@unina.it. 5. Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy. acampa@unina.it.
Abstract
BACKGROUND: Breast attenuation may impact the diagnostic accuracy of stress myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT). We compared the performance of conventional (C)-SPECT and cadmium-zinc-telluride (CZT)-SPECT systems in women with low-intermediate likelihood of coronary artery disease (CAD). METHODS AND RESULTS: A total of 109 consecutive women underwent stress-optional rest MPI by both C-SPECT and CZT-SPECT. In the overall study population, a weak albeit significant correlation between total perfusion defect (TPD) measured by C-SPECT and CZT-SPECT was observed (r = 0.38, P < .001) and at Bland-Altman analysis the mean difference in TPD (C-SPECT minus CZT-SPECT) was 2.40% (P < .001). Overall concordance of semi-quantitative diagnostic performance between C-SPECT and CZT-SPECT was observed in 52 (48%) women with a κ value of 0.09. Normalcy rate was significantly higher using CZT-SPECT compared to C-SPECT (P < .001). Machine learning analysis performed through the implementation of J48 algorithm proved that CZT-SPECT has higher sensitivity, specificity, and accuracy than C-SPECT. CONCLUSIONS: In women with low-intermediate likelihood of CAD, there is a poor concordance of diagnostic performance between C-SPECT and CZT-SPECT, and CZT-SPECT allows better normalcy rate detection compared to C-SPECT.
BACKGROUND: Breast attenuation may impact the diagnostic accuracy of stress myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT). We compared the performance of conventional (C)-SPECT and cadmium-zinc-telluride (CZT)-SPECT systems in women with low-intermediate likelihood of coronary artery disease (CAD). METHODS AND RESULTS: A total of 109 consecutive women underwent stress-optional rest MPI by both C-SPECT and CZT-SPECT. In the overall study population, a weak albeit significant correlation between total perfusion defect (TPD) measured by C-SPECT and CZT-SPECT was observed (r = 0.38, P < .001) and at Bland-Altman analysis the mean difference in TPD (C-SPECT minus CZT-SPECT) was 2.40% (P < .001). Overall concordance of semi-quantitative diagnostic performance between C-SPECT and CZT-SPECT was observed in 52 (48%) women with a κ value of 0.09. Normalcy rate was significantly higher using CZT-SPECT compared to C-SPECT (P < .001). Machine learning analysis performed through the implementation of J48 algorithm proved that CZT-SPECT has higher sensitivity, specificity, and accuracy than C-SPECT. CONCLUSIONS: In women with low-intermediate likelihood of CAD, there is a poor concordance of diagnostic performance between C-SPECT and CZT-SPECT, and CZT-SPECT allows better normalcy rate detection compared to C-SPECT.
Authors: G Germano; P B Kavanagh; P Waechter; J Areeda; S Van Kriekinge; T Sharir; H C Lewin; D S Berman Journal: J Nucl Med Date: 2000-04 Impact factor: 10.057
Authors: Piotr J Slomka; Hidetaka Nishina; Daniel S Berman; Xingping Kang; John D Friedman; Sean W Hayes; Usaf E Aladl; Guido Germano Journal: J Nucl Med Date: 2004-02 Impact factor: 10.057
Authors: Valeria Cantoni; Roberta Green; Carlo Ricciardi; Roberta Assante; Leandro Donisi; Emilia Zampella; Giuseppe Cesarelli; Carmela Nappi; Vincenzo Sannino; Valeria Gaudieri; Teresa Mannarino; Andrea Genova; Giovanni De Simini; Alessia Giordano; Adriana D'Antonio; Wanda Acampa; Mario Petretta; Alberto Cuocolo Journal: Comput Math Methods Med Date: 2021-10-16 Impact factor: 2.238