| Literature DB >> 31221830 |
Yu Wang1, Chenzhou Zhang2, Nini Wang1, Zhipeng Li3, Rasmus Heller4, Rong Liu5,6, Yue Zhao1, Jiangang Han7, Xiangyu Pan1, Zhuqing Zheng1, Xueqin Dai5,6, Ceshi Chen5,6, Mingle Dou1, Shujun Peng1, Xianqing Chen2, Jing Liu1, Ming Li1, Kun Wang2, Chang Liu2, Zeshan Lin2, Lei Chen2, Fei Hao8, Wenbo Zhu2, Chengchuang Song1, Chen Zhao1, Chengli Zheng9, Jianming Wang9, Shengwei Hu10, Cunyuan Li10, Hui Yang8, Lin Jiang7, Guangyu Li3, Mingjun Liu11, Tad S Sonstegard12, Guojie Zhang6,13,14,15, Yu Jiang16, Wen Wang17,6,14, Qiang Qiu17.
Abstract
Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.Entities:
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Year: 2019 PMID： 31221830 DOI： 10.1126/science.aav6335
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728