Literature DB >> 31221776

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.

Tianxiang Hu1, Yating Chong2, Sumin Lu2, Meaghan McGuinness3, David A Williams3, John K Cowell2.   

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Year:  2020        PMID： 31221776      PMCID： PMC7012474          DOI： 10.3324/haematol.2018.208058

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  15 in total

1.  Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.

Authors:  Young Jin Cho; Jess M Cunnick; Sun-Ju Yi; Vesa Kaartinen; John Groffen; Nora Heisterkamp
Journal:  Mol Cell Biol       Date:  2006-11-20       Impact factor: 4.272

Review 2.  GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo.

Authors:  Xosé R Bustelo; Vincent Sauzeau; Inmaculada M Berenjeno
Journal:  Bioessays       Date:  2007-04       Impact factor: 4.345

3.  Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.

Authors:  Brenda L Montalvo-Ortiz; Linette Castillo-Pichardo; Eliud Hernández; Tessa Humphries-Bickley; Alina De la Mota-Peynado; Luis A Cubano; Cornelis P Vlaar; Suranganie Dharmawardhane
Journal:  J Biol Chem       Date:  2012-03-01       Impact factor: 5.157

4.  Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen.

Authors:  Brock Grill; John W Schrader
Journal:  Blood       Date:  2002-11-01       Impact factor: 22.113

5.  Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.

Authors:  Amitava Sengupta; Jorden Arnett; Susan Dunn; David A Williams; Jose A Cancelas
Journal:  Blood       Date:  2010-04-20       Impact factor: 22.113

6.  Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

Authors:  Emily K Thomas; Jose A Cancelas; Hee-Don Chae; Adrienne D Cox; Patricia J Keller; Danilo Perrotti; Paolo Neviani; Brian J Druker; Kenneth D R Setchell; Yi Zheng; Chad E Harris; David A Williams
Journal:  Cancer Cell       Date:  2007-11       Impact factor: 31.743

7.  Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

Authors:  Fukun Guo; Jose A Cancelas; David Hildeman; David A Williams; Yi Zheng
Journal:  Blood       Date:  2008-06-25       Impact factor: 22.113

8.  Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-fibroblast growth factor receptor-1 chimeric tyrosine kinase.

Authors:  Mingqiang Ren; Xiurong Li; John K Cowell
Journal:  Blood       Date:  2009-06-08       Impact factor: 22.113

9.  Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage.

Authors:  Mingqiang Ren; Josephine A Tidwell; Suash Sharma; John K Cowell
Journal:  PLoS One       Date:  2012-06-06       Impact factor: 3.240

10.  SCLLTargeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models.

Authors:  Qing Wu; Aaron Bhole; Haiyan Qin; Judith Karp; Sami Malek; John K Cowell; Mingqiang Ren
Journal:  Oncotarget       Date:  2016-08-02
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  1 in total

1.  The Mechanism of Rac1 in Regulating HCC Cell Glycolysis Which Provides Underlying Therapeutic Target for HCC Therapy.

Authors:  Yin-Xiang Ren; Xiao-Bin Li; Wei Liu; Xu-Guang Yang; Xin Liu; Yu Luo
Journal:  J Oncol       Date:  2022-07-06       Impact factor: 4.501
  1 in total

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