Tandi E Matsha1, Saaiga Ismail2, Aladdin Speelman2, Gloudina M Hon3, Saarah Davids3, Rajiv T Erasmus4, Andre P Kengne5. 1. SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa. Electronic address: matshat@cput.ac.za. 2. SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa; MITS, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa. 3. SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa. 4. Division of Chemical Pathology, Faculty of Health Sciences, National Health Laboratory Service (NHLS) and University of Stellenbosch, Cape Town, South Africa. 5. Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa.
Abstract
BACKGROUND AND AIMS: A number of studies concur that visceral abdominal tissue (VAT) is a metabolic organ that mostly contributes to the metabolic consequences of obesity, however reports regarding subcutaneous adipose tissue (SAT) are controversial. We aimed to investigate the association between computed tomography measured visceral and subcutaneous adipose tissue and metabolic syndrome as well as its individual components. METHODS: Computed tomography at level L4/L5 intervertebral disc space was performed in 401 mixed ancestry individuals from the Bellville South community of Cape Town. Data collections included OGTT, anthropometric, blood pressure, lipids, insulin cotinine, and alcohol consumption history. RESULTS: Both VAT and SAT were increased in subjects with metabolic syndrome (p < 0.0001). In logistic regression, adjusted for age, gender, BMI, smoking, alcohol use, hypertension, diabetes and dyslipidaemia treatment (for women also adjusted for menopausal age) increasing quartiles of VAT were associated with metabolic syndrome {odds ratio (95% confidence interval) ≥ 4.14 (1.92-8.93), p < 0.001} and any type of hyperglycaemia (≥4.45 (1.89-10.47), p ≤ 0.001) whilst decreasing quartiles of SAT were associated with metabolic syndrome, p ≤ 0.037. In gender specific multivariate linear regression models, increased SAT levels were associated with 2-h plasma glucose, insulin levels and triglycerides in men, β ≥ 0.999, p ≤ 0.01. CONCLUSIONS: Our study shows that increased VAT and decreased SAT are associated with metabolic syndrome in women, but in men increased SAT has deleterious effects to metabolic syndrome components. Therefore, in men increased SAT may like VAT increase the risk of diabetes development.
BACKGROUND AND AIMS: A number of studies concur that visceral abdominal tissue (VAT) is a metabolic organ that mostly contributes to the metabolic consequences of obesity, however reports regarding subcutaneous adipose tissue (SAT) are controversial. We aimed to investigate the association between computed tomography measured visceral and subcutaneous adipose tissue and metabolic syndrome as well as its individual components. METHODS: Computed tomography at level L4/L5 intervertebral disc space was performed in 401 mixed ancestry individuals from the Bellville South community of Cape Town. Data collections included OGTT, anthropometric, blood pressure, lipids, insulincotinine, and alcohol consumption history. RESULTS: Both VAT and SAT were increased in subjects with metabolic syndrome (p < 0.0001). In logistic regression, adjusted for age, gender, BMI, smoking, alcohol use, hypertension, diabetes and dyslipidaemia treatment (for women also adjusted for menopausal age) increasing quartiles of VAT were associated with metabolic syndrome {odds ratio (95% confidence interval) ≥ 4.14 (1.92-8.93), p < 0.001} and any type of hyperglycaemia (≥4.45 (1.89-10.47), p ≤ 0.001) whilst decreasing quartiles of SAT were associated with metabolic syndrome, p ≤ 0.037. In gender specific multivariate linear regression models, increased SAT levels were associated with 2-h plasma glucose, insulin levels and triglycerides in men, β ≥ 0.999, p ≤ 0.01. CONCLUSIONS: Our study shows that increased VAT and decreased SAT are associated with metabolic syndrome in women, but in men increased SAT has deleterious effects to metabolic syndrome components. Therefore, in men increased SAT may like VAT increase the risk of diabetes development.
Authors: Zixing Ye; He Xiao; Guanghua Liu; Yi Qiao; Yi Zhao; Zhigang Ji; Xiaohong Fan; Rongrong Li; Ou Wang Journal: Front Endocrinol (Lausanne) Date: 2022-06-30 Impact factor: 6.055