| Literature DB >> 31220568 |
Shayan Amiri1, Sanaz Dastghaib2, Mazaher Ahmadi3, Parvaneh Mehrbod4, Forough Khadem5, Hamid Behrouj2, Mohamad-Reza Aghanoori6, Filip Machaj7, Mahdi Ghamsari3, Jakub Rosik7, Andrzej Hudecki8, Abbas Afkhami3, Mohammad Hashemi9, Marek J Los10, Pooneh Mokarram2, Tayyebeh Madrakian3, Saeid Ghavami11.
Abstract
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids which possess a wide range of pharmacological activities. Recent evidence indicates that B and BA have several properties useful for the treatment of metabolic disorders, infectious diseases, cardiovascular disorders, and neurological disorders. In the current review, we discuss B and BA structures and derivatives and then comprehensively explain their pharmacological effects in relation to various diseases. We also explain antiviral, antibacterial and anti-cancer effects of B and BA. Finally, we discuss the delivery methods, in which these compounds most effectively target different systems.Entities:
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Year: 2019 PMID： 31220568 DOI： 10.1016/j.biotechadv.2019.06.008
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227