Juan Carlos H Hernández-Rivera1, Mariana Salazar-Mendoza2, María Juana Pérez-López3, Jaime González-Ramos4, Ramón Espinoza-Pérez5, Julio César Martínez-Álvarez6, Miguel Trejo-Villeda1, Ramón Paniagua-Sierra1. 1. Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Unidad de Investigación Médica en Enfermedades Nefrológicas. Ciudad de México, México. 2. Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Hospital Regional "Lic. Adolfo López Mateos", Servicio de Urgencias. Ciudad de México, México. 3. Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Servicio de Nefrología. Ciudad de México, México. 4. Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Laboratorio de Histocompatibilidad. Ciudad de México, México. 5. Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Unidad de Trasplante Renal. Ciudad de México, México. 6. Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Laboratorio de Histocompatibilidad. Ciudad de México, México.
Abstract
INTRODUCTION: Chronic kidney disease accounts for part of overall health expenditure; a potential etiology is related to variations, absence or presence of some human leukocyte antigen (HLA) alleles. METHOD: An analysis of HLA reports of 1965 kidney recipients with no determined etiology, and 1361 kidney donors was performed. It was carried out with Luminex based in cell flow fluorometry for the A, B, DRB1 and DQA loci. An analysis was performed with contingency tables in order to determine the odds ratio (OR) and confidence intervals (CI). Quantitative analysis was also carried out. RESULTS: Of the 101 alleles found, 13 showed association, 7 with risk for chronic kidney disease, with the most significant being HLA-DR17 with an OR of 3.91 (95 % CI = 2.96-5.17) and the one with the highest significance for protection being HLA-DR9, with an OR of 0.043 (95 % CI = 0.005-0.3224). CONCLUSIONS: It is necessary to understand that kidney diseases can be associated with yet unknown immune processes, where the association of the absence or presence of any allele should be known. Copyright:
INTRODUCTION: Chronic kidney disease accounts for part of overall health expenditure; a potential etiology is related to variations, absence or presence of some human leukocyte antigen (HLA) alleles. METHOD: An analysis of HLA reports of 1965 kidney recipients with no determined etiology, and 1361 kidney donors was performed. It was carried out with Luminex based in cell flow fluorometry for the A, B, DRB1 and DQA loci. An analysis was performed with contingency tables in order to determine the odds ratio (OR) and confidence intervals (CI). Quantitative analysis was also carried out. RESULTS: Of the 101 alleles found, 13 showed association, 7 with risk for chronic kidney disease, with the most significant being HLA-DR17 with an OR of 3.91 (95 % CI = 2.96-5.17) and the one with the highest significance for protection being HLA-DR9, with an OR of 0.043 (95 % CI = 0.005-0.3224). CONCLUSIONS: It is necessary to understand that kidney diseases can be associated with yet unknown immune processes, where the association of the absence or presence of any allele should be known. Copyright: