Literature DB >> 31219109

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence.

Rahul T Kadakia1, Da Xie, Daniel Martinez, Meng Yu, Emily L Que.   

Abstract

We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

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Year:  2019        PMID： 31219109      PMCID： PMC6650319          DOI： 10.1039/c9cc00375d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions.

Authors:  S A Amali S Subasinghe; Robia G Pautler; Md Abul Hassan Samee; Jason T Yustein; Matthew J Allen
Journal:  Biosensors (Basel)       Date:  2022-06-30

Review 2.  Perfluorocarbons-Based 19F Magnetic Resonance Imaging in Biomedicine.

Authors:  Lina Wu; Fang Liu; Shuang Liu; Xiuan Xu; Zhaoxi Liu; Xilin Sun
Journal:  Int J Nanomedicine       Date:  2020-10-02

Review 3.  Bioimaging agents based on redox-active transition metal complexes.

Authors:  Shan-Shan Xue; Yingbo Pan; Wei Pan; Shujie Liu; Na Li; Bo Tang
Journal:  Chem Sci       Date:  2022-07-27       Impact factor: 9.969

Review 4.  The Design of Abnormal Microenvironment Responsive MRI Nanoprobe and Its Application.

Authors:  Ancong Wang; Xiao Han; Wenliu Qi; Sihui Du; Zhenqi Jiang; Xiaoying Tang
Journal:  Int J Mol Sci       Date:  2021-05-13       Impact factor: 5.923
  4 in total

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