Xinke Liu1, Zihao Zhang2,3, Chengcheng Zhu4, Junqiang Feng1, Peng Liu1, Qingle Kong2,5, Xianchang Zhang2,5, Qiang Zhang6, Hengwei Jin1, Huijian Ge1, Yuhua Jiang7, David Saloner4, Youxiang Li8. 1. Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 2. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 3. The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China. 4. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA. 5. University of Chinese Academy of Sciences, Beijing, China. 6. Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China. 7. Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. jxy_200321@163.com. 8. Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. liyouxiang@263.net.
Abstract
PURPOSE: To evaluate and compare wall enhancement patterns in saccular and fusiform intracranial aneurysms using high-resolution black-blood MRI at 7 T. METHODS: Thirty-one patients with 32 unruptured intracranial aneurysms (21 saccular and 11 fusiform) underwent 7-T black-blood MRI. Aneurysm wall enhancement (AWE) was categorized as follows: no wall enhancement (NWE), focal wall enhancement (FWE), and uniform wall enhancement (UWE). The degree of enhancement was scored as follows: 0 (no enhancement), 1 (signal intensity (SI) of the aneurysm wall less than that of the pituitary infundibulum), and 2 (equal to that of the pituitary infundibulum). The chi-squared test was used to compare the AWE pattern and degree between saccular and fusiform aneurysms. RESULTS: In saccular aneurysms, 12/21 (57%) enhanced. Of these, 9 showed FWE (5 grade 1 and 4 grade 2), and 3 showed UWE (2 grade 1 and 1 grade 2). In fusiform aneurysms, 11/11 (100%) enhanced. Of these, 1 showed FWE and 10 showed UWE. All fusiform aneurysms had grade-2 enhancement. Fusiform aneurysms had more extensive and higher SI AWE than saccular aneurysms (p < 0.01) despite having a similar size (6.9 ± 3.0 mm vs. 8.0 ± 2.9, p = 0.23). For saccular aneurysm, larger aneurysm size was correlated with higher degree of enhancement with Pearson's r = 0.64 (p = 0.002). CONCLUSION: Intracranial fusiform aneurysms had enhancement of higher SI and that covered a more extensive area than saccular aneurysms, which might indicate differences in vessel wall pathology. KEY POINTS: • Intracranial aneurysm wall enhancement can be reliably characterized by 7-T black-blood MRI. • AWE in intracranial fusiform aneurysms presents over a larger surface area and with greater signal intensity as compared with that in saccular aneurysms, which might indicate differences in pathology. • Stronger signal intensity of AWE correlates with the aneurysm size in saccular aneurysms.
PURPOSE: To evaluate and compare wall enhancement patterns in saccular and fusiform intracranial aneurysms using high-resolution black-blood MRI at 7 T. METHODS: Thirty-one patients with 32 unruptured intracranial aneurysms (21 saccular and 11 fusiform) underwent 7-T black-blood MRI. Aneurysm wall enhancement (AWE) was categorized as follows: no wall enhancement (NWE), focal wall enhancement (FWE), and uniform wall enhancement (UWE). The degree of enhancement was scored as follows: 0 (no enhancement), 1 (signal intensity (SI) of the aneurysm wall less than that of the pituitary infundibulum), and 2 (equal to that of the pituitary infundibulum). The chi-squared test was used to compare the AWE pattern and degree between saccular and fusiform aneurysms. RESULTS: In saccular aneurysms, 12/21 (57%) enhanced. Of these, 9 showed FWE (5 grade 1 and 4 grade 2), and 3 showed UWE (2 grade 1 and 1 grade 2). In fusiform aneurysms, 11/11 (100%) enhanced. Of these, 1 showed FWE and 10 showed UWE. All fusiform aneurysms had grade-2 enhancement. Fusiform aneurysms had more extensive and higher SI AWE than saccular aneurysms (p < 0.01) despite having a similar size (6.9 ± 3.0 mm vs. 8.0 ± 2.9, p = 0.23). For saccular aneurysm, larger aneurysm size was correlated with higher degree of enhancement with Pearson's r = 0.64 (p = 0.002). CONCLUSION:Intracranial fusiform aneurysms had enhancement of higher SI and that covered a more extensive area than saccular aneurysms, which might indicate differences in vessel wall pathology. KEY POINTS: • Intracranial aneurysm wall enhancement can be reliably characterized by 7-T black-blood MRI. • AWE in intracranial fusiform aneurysms presents over a larger surface area and with greater signal intensity as compared with that in saccular aneurysms, which might indicate differences in pathology. • Stronger signal intensity of AWE correlates with the aneurysm size in saccular aneurysms.
Entities:
Keywords:
Fusiform aneurysm; Gadolinium; Magnetic resonance imaging; Pathology; Saccular aneurysm
Authors: Daan Backes; Jeroen Hendrikse; Irene van der Schaaf; Ale Algra; Antti E Lindgren; Bon H Verweij; Gabriel J E Rinkel; Mervyn D I Vergouwen Journal: Neurosurgery Date: 2018-10-01 Impact factor: 4.654
Authors: Rachel Kleinloog; Emine Korkmaz; Jaco J M Zwanenburg; Hugo J Kuijf; Fredy Visser; Roos Blankena; Jan A Post; Ynte M Ruigrok; Peter R Luijten; Luca Regli; Gabriel J E Rinkel; Bon H Verweij Journal: Neurosurgery Date: 2014-12 Impact factor: 4.654
Authors: Nikki Dieleman; Anja G van der Kolk; Jaco J M Zwanenburg; Anita A Harteveld; Geert J Biessels; Peter R Luijten; Jeroen Hendrikse Journal: Circulation Date: 2014-07-08 Impact factor: 29.690
Authors: S Nagahata; M Nagahata; M Obara; R Kondo; N Minagawa; S Sato; S Sato; W Mouri; S Saito; T Kayama Journal: Clin Neuroradiol Date: 2014-10-21 Impact factor: 3.649
Authors: N Larsen; C von der Brelie; D Trick; C H Riedel; T Lindner; J Madjidyar; O Jansen; M Synowitz; C Flüh Journal: AJNR Am J Neuroradiol Date: 2018-07-19 Impact factor: 3.825
Authors: Ashrita Raghuram; Alberto Varon; Sebastian Sanchez; Daizo Ishii; Chaorong Wu; Vincent A Magnotta; David M Hasan; Timothy R Koscik; Edgar A Samaniego Journal: Stroke Vasc Interv Neurol Date: 2022-05-08