C Floridi1,2, A Carnevale3, E M Fumarola4, S Schampaert5, F Fontana6, D De Palma7, A Del Sole8, M Giganti9, G Carrafiello4. 1. Department of Health Sciences, Diagnostic and Interventional Radiology, San Paolo Hospital, University of Milan, Milan, Italy. chiara.floridi@gmail.com. 2. Diagnostic and Interventional Radiology Department, San Paolo Hospital, Via Di Rudinì, 20121, Milan, Italy. chiara.floridi@gmail.com. 3. University Radiology Unit, Department of Radiology, University Hospital of Ferrara, Ferrara, Italy. 4. Department of Health Sciences, Diagnostic and Interventional Radiology, San Paolo Hospital, University of Milan, Milan, Italy. 5. Image-Guided Therapy Systems, Philips Healthcare, Best, The Netherlands. 6. Radiology Department, Ospedale di Circolo e Fondazione Macchi, Varese, Italy. 7. Department of Nuclear Medicine, Ospedale di Circolo e Fondazione Macchi, Varese, Italy. 8. Nuclear Medicine Unit, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy. 9. Department of Morphology, Surgery and Experimental Medicine, Section of Radiology, University of Ferrara, Ferrara, Italy.
Abstract
PURPOSE: The aim of this study is to evaluate the feasibility of percutaneous lung tumor biopsy under cone beam-computed tomography (CBCT) with PET-CT imaging fusion. MATERIALS AND METHODS: Eleven patients (four women and seven men) underwent C-arm CBCT lung biopsy with PET-CT fusion imaging. A preprocedural PET-CT scan was manually fused with procedural CBCT based on anatomical landmarks; using real-time fluoroscopy, the coregistered PET-CT and CBCT images were overlaid to guide the needle trajectory. Technical success, accuracy, sensibility and specificity were evaluated. Mean total procedure time and time required for image elaboration were recorded. RESULTS: Technical success, diagnostic accuracy, sensitivity and specificity were 100%. The mean procedure time was 38 min. The average time of PET-CT/CBCT image fusion elaboration was 3.53 min for planning and 3.42 min for needle positioning check. CONCLUSION: CBCT-guided percutaneous lung biopsy with PET-CT fusion imaging is a feasible and effective procedure, with the potential to further improve diagnostic yield by targeting the most metabolically active portion of a lesion, whether it is morphologically altered or normal.
PURPOSE: The aim of this study is to evaluate the feasibility of percutaneous lung tumor biopsy under cone beam-computed tomography (CBCT) with PET-CT imaging fusion. MATERIALS AND METHODS: Eleven patients (four women and seven men) underwent C-arm CBCT lung biopsy with PET-CT fusion imaging. A preprocedural PET-CT scan was manually fused with procedural CBCT based on anatomical landmarks; using real-time fluoroscopy, the coregistered PET-CT and CBCT images were overlaid to guide the needle trajectory. Technical success, accuracy, sensibility and specificity were evaluated. Mean total procedure time and time required for image elaboration were recorded. RESULTS: Technical success, diagnostic accuracy, sensitivity and specificity were 100%. The mean procedure time was 38 min. The average time of PET-CT/CBCT image fusion elaboration was 3.53 min for planning and 3.42 min for needle positioning check. CONCLUSION: CBCT-guided percutaneous lung biopsy with PET-CT fusion imaging is a feasible and effective procedure, with the potential to further improve diagnostic yield by targeting the most metabolically active portion of a lesion, whether it is morphologically altered or normal.
Authors: Martina Gurgitano; Salvatore Alessio Angileri; Giovanni Maria Rodà; Alessandro Liguori; Marco Pandolfi; Anna Maria Ierardi; Bradford J Wood; Gianpaolo Carrafiello Journal: Radiol Med Date: 2021-04-16 Impact factor: 3.469
Authors: Marco Pandolfi; Alessandro Liguori; Martina Gurgitano; Antonio Arrichiello; Letizia Di Meglio; Giovanni Maria Rodà; Alice Guadagni; Salvatore Alessio Angileri; Anna Maria Ierardi; Giorgio Buccimazza; Daniela Donat; Aldo Paolucci; Gianpaolo Carrafiello Journal: Acta Biomed Date: 2020-09-23
Authors: Serena Carriero; Gianmarco Della Pepa; Lorenzo Monfardini; Renato Vitale; Duccio Rossi; Andrea Masperi; Giovanni Mauri Journal: Diagnostics (Basel) Date: 2021-03-19