| Literature DB >> 3121742 |
V E Kelley1, G N Gaulton, M Hattori, H Ikegami, G Eisenbarth, T B Strom.
Abstract
In order to assess the importance of interleukin 2 receptor (IL-2R)-positive activated lymphocytes and macrophages in the pathogenesis of autoimmunity, we tested the prophylactic therapeutic efficacy of an anti-IL-2R (M7/20) monoclonal antibody, which recognizes the 55-kDa subunit of the heterodimeric IL-2R in two distinct models: the nonobese diabetic mouse and the NZB x NZW F1 hybrid with lupus. Treatment with anti-IL-2R monoclonal antibody suppressed autoimmune insulitis in nonobese diabetic mice and lupus nephritis in the NZB x NZW F1 hybrid. These studies indicate that highly selective targeting to activated lymphocytes and macrophages expressing the IL-2R provides a discrete method of dampening autoimmunity.Entities:
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Year: 1988 PMID： 3121742
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422