Literature DB >> 312165

The effect of diethylcarbamazine in a murine model of Brugia malayi microfilaraemia.

M Neill, J W Kazura.   

Abstract

The effect of diethylcarbamazine was tested in a murine model of Brugia malayi microfilaraemia. A course of therapy similar to that used to treat human infection led to more than a 90% decrease in circulating parasites. Experiments in which different amounts of diethylcarbamazine were given as a single dose indicated that its microfilaricidal activity is dose-dependent. The animal model of B. malayi microfilaraemia may be useful for studies of the mechanism of action and pharmacology of diethylcarbamazine and may be applied to the screening of new microfilaricidal drugs.

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Year:  1979        PMID： 312165      PMCID： PMC2395783     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  3 in total

1.  Studies on filariasis in Malaya: a trial mass treatment of Wuchereria malayi filariasis with single daily doses of diethylcarbamazine.

Authors:  L H TURNER; L S SODHY
Journal:  Ann Trop Med Parasitol       Date:  1959-09

2.  Studies on filariasis in Malaya: the effect of diethylcarbamazine on Brugia malayi and B. pahangi in domestic cats.

Authors:  J F EDESON; A B LAING
Journal:  Ann Trop Med Parasitol       Date:  1959-12

3.  The maintenance of a filarial infection (Litomosoides carinii) for chemotherapeutic investigations.

Authors:  F HAWKING; P SEWELL
Journal:  Br J Pharmacol Chemother       Date:  1948-12
  3 in total
  2 in total

1.  Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.

Authors:  Helen F McGarry; Leigh D Plant; Mark J Taylor
Journal:  Filaria J       Date:  2005-06-02

2.  Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.

Authors:  Raman Sharma; Ghaith Al Jayoussi; Hayley E Tyrer; Joanne Gamble; Laura Hayward; Ana F Guimaraes; Jill Davies; David Waterhouse; Darren A N Cook; Laura J Myhill; Rachel H Clare; Andrew Cassidy; Andrew Steven; Kelly L Johnston; Louise Ford; Joseph D Turner; Stephen A Ward; Mark J Taylor
Journal:  Sci Rep       Date:  2016-03-21       Impact factor: 4.379
  2 in total

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