Literature DB >> 3121550

Catechol strongly enhances rat stomach carcinogenesis: a possible new environmental stomach carcinogen.

M Hirose1, Y Kurata, H Tsuda, S Fukushima, N Ito.   

Abstract

Catechol (CAS: 120-80-9) is present in the environment, being a major industrial chemical as well as a major phenolic component of cigarette smoke. Continuous oral treatment of rats with 0.8% catechol for 51 weeks after a single intragastric dose of 150 mg/kg of N-methyl-N'-nitro-N-nitrosoguanidine strongly enhanced both forestomach and glandular stomach carcinogenesis. In addition, and more importantly, catechol alone induced adenocarcinoma and adenomatous hyperplasia in the pyloric region of the glandular stomach. These results clearly indicate that this environmental contaminant merits classification as an enhancer of forestomach and glandular stomach carcinogenesis with complete carcinogenic potential for the glandular stomach. Its significance for gastric tumor development in man requires elucidation.

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Year:  1987        PMID： 3121550

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  9 in total

Review 1.  Gastric carcinogenesis: diet as a causative factor.

Authors:  T Sugimura; K Wakabayashi
Journal:  Med Oncol Tumor Pharmacother       Date:  1990

Review 2.  Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice.

Authors:  J E Huff; J K Haseman; D M DeMarini; S Eustis; R R Maronpot; A C Peters; R L Persing; C E Chrisp; A C Jacobs
Journal:  Environ Health Perspect       Date:  1989-07       Impact factor: 9.031

3.  Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.

Authors:  M Hirose; S Fukushima; T Shirai; R Hasegawa; T Kato; H Tanaka; E Asakawa; N Ito
Journal:  Jpn J Cancer Res       Date:  1990-03

4.  Dose-dependent promoting effects of catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N-methyl-N-nitrosourea.

Authors:  K Kobayashi; N Shimizu; T Tsukamoto; K Inada; H Nakanishi; K Goto; M Mutai; M Tatematsu
Journal:  Jpn J Cancer Res       Date:  1997-12

5.  The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989.

Authors:  L S Gold; N B Manley; T H Slone; G B Garfinkel; L Rohrbach; B N Ames
Journal:  Environ Health Perspect       Date:  1993-04       Impact factor: 9.031

6.  Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats.

Authors:  S Fukushima; A Hagiwara; M Hirose; S Yamaguchi; D Tiwawech; N Ito
Journal:  Jpn J Cancer Res       Date:  1991-06

7.  Possible tumor-initiating and -promoting activity of p-methylcatechol and methylhydroquinone in the pyloric mucosa of rat stomach.

Authors:  C Furihata; S Oguchi; T Matsushima
Journal:  Jpn J Cancer Res       Date:  1993-03

8.  Inductions of ornithine decarboxylase and replicative DNA synthesis but not DNA single strand scission or unscheduled DNA synthesis in the pyloric mucosa of rat stomach by catechol.

Authors:  C Furihata; A Hatta; T Matsushima
Journal:  Jpn J Cancer Res       Date:  1989-11

9.  Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.

Authors:  S Fukushima; M A Shibata; M Hirose; T Kato; M Tatematsu; N Ito
Journal:  Jpn J Cancer Res       Date:  1991-07
  9 in total

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