Ping Yin1, Ning Mao2, Xia Liu1, Chao Sun1, Sicong Wang3, Lei Chen1, Nan Hong1. 1. Department of Radiology, Peking University People's Hospital, Beijing, P.R. China. 2. Department of Radiology, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, Shandong, P.R. China. 3. GE Healthcare, Shanghai, China.
Abstract
BACKGROUND: Chondrosarcoma (CS) is the second most common primary malignant bone tumor, with a relatively high recurrence rate. However, an effective method that estimates whether pelvic CS will recur after surgery, which influences the formulation of a clinical treatment plan, remains lacking. PURPOSE: To develop and validate a clinical radiomics nomograms based on 3D multiparametric magnetic resonance imaging (mpMRI) features and clinical characteristics that could estimate early recurrence (ER) (≤1 year) of pelvic CS. STUDY TYPE: Retrospective. POPULATION: In all, 103 patients (ER = 41, non-ER = 62) with histologically proven CS were retrospectively analyzed and divided into a training set (n = 72) and a validation set (n = 31). FIELD STRENGTH/SEQUENCE: 3.0T axial T1 -weighted (T1 -w), T2 -weighted (T2 -w), diffusion weighted imaging (DWI), contrast-enhanced T1 -weighted (CET1 -w). ASSESSMENT: Risk factors (sex, age, type, grade, resection margins, etc.) associated with ER were evaluated. Five individual models based on T1 -w, T2 -w, DWI, CET1 -w, and clinical data were built. Then we compared the performance of models based on T1 -w, T2 -w, CET1 -w and their combination. Lastly, two nomograms based on the best model + clinical data and DWI + clinical data were built. STATISTICAL TESTS: The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models. RESULTS: Grade was the most important univariate clinical predictor of ER of pelvic CS patients (odds ratio [OR]1 = 4.616, OR2 = 8.939, P < 0.05). T1 -w + T2 -w + CET1 -w had a significantly higher performance than CET1 -w in the training set (P = 0.01). Radiomics features are more important than clinical characteristics in clinical radiomics nomograms, especially for multisequence combined features (OR = 3.208, P < 0.01). Clinical radiomics nomogram based on combined features (T1 -w + T2 -w + CET1 -w) + clinical data achieved an AUC of 0.891 and ACC of 0.857, followed by DWI + clinical data (AUC = 0.882, ACC = 0.760) in the validation set. DATA CONCLUSION: The clinical radiomics nomogram had good performance in estimating ER of pelvic CS patients, which would be helpful in clinical decision-making. LEVEL OF EVIDENCE: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:435-445.
BACKGROUND:Chondrosarcoma (CS) is the second most common primary malignant bone tumor, with a relatively high recurrence rate. However, an effective method that estimates whether pelvic CS will recur after surgery, which influences the formulation of a clinical treatment plan, remains lacking. PURPOSE: To develop and validate a clinical radiomics nomograms based on 3D multiparametric magnetic resonance imaging (mpMRI) features and clinical characteristics that could estimate early recurrence (ER) (≤1 year) of pelvic CS. STUDY TYPE: Retrospective. POPULATION: In all, 103 patients (ER = 41, non-ER = 62) with histologically proven CS were retrospectively analyzed and divided into a training set (n = 72) and a validation set (n = 31). FIELD STRENGTH/SEQUENCE: 3.0T axial T1 -weighted (T1 -w), T2 -weighted (T2 -w), diffusion weighted imaging (DWI), contrast-enhanced T1 -weighted (CET1 -w). ASSESSMENT: Risk factors (sex, age, type, grade, resection margins, etc.) associated with ER were evaluated. Five individual models based on T1 -w, T2 -w, DWI, CET1 -w, and clinical data were built. Then we compared the performance of models based on T1 -w, T2 -w, CET1 -w and their combination. Lastly, two nomograms based on the best model + clinical data and DWI + clinical data were built. STATISTICAL TESTS: The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models. RESULTS: Grade was the most important univariate clinical predictor of ER of pelvic CS patients (odds ratio [OR]1 = 4.616, OR2 = 8.939, P < 0.05). T1 -w + T2 -w + CET1 -w had a significantly higher performance than CET1 -w in the training set (P = 0.01). Radiomics features are more important than clinical characteristics in clinical radiomics nomograms, especially for multisequence combined features (OR = 3.208, P < 0.01). Clinical radiomics nomogram based on combined features (T1 -w + T2 -w + CET1 -w) + clinical data achieved an AUC of 0.891 and ACC of 0.857, followed by DWI + clinical data (AUC = 0.882, ACC = 0.760) in the validation set. DATA CONCLUSION: The clinical radiomics nomogram had good performance in estimating ER of pelvic CS patients, which would be helpful in clinical decision-making. LEVEL OF EVIDENCE: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:435-445.
Authors: Ning Mao; Yi Dai; Fan Lin; Heng Ma; Shaofeng Duan; Haizhu Xie; Wenlei Zhao; Nan Hong Journal: Front Oncol Date: 2020-10-27 Impact factor: 6.244
Authors: Agnieszka E Zając; Sylwia Kopeć; Bartłomiej Szostakowski; Mateusz J Spałek; Michał Fiedorowicz; Elżbieta Bylina; Paulina Filipowicz; Anna Szumera-Ciećkiewicz; Andrzej Tysarowski; Anna M Czarnecka; Piotr Rutkowski Journal: Cancers (Basel) Date: 2021-05-14 Impact factor: 6.639