[Induction of unstable mutations in Drosophila melanogaster by microinjection of DNA from oncogenic viruses into the embryonic polar plasma. III. Genetic instability in the absence of an intact P-element].

DNA of simian adenovirus Sa7 injected into polar plasma of early Drosophila melanogaster y1snw*; bw; st stock embryos induced one to three unstable visible X-linked mutations in the absence of intact P-element. Numerous mutational events (reversions, new mutations) occur only in four precisely destabilized by the Sa7 DNA loci of X-chromosome and take place during 4-5 generations; in the next generations the level of instability decreased. At the same time, Sa7 DNA induced reversions and new allelic mutations in the snw mutant locus, without exogenous intact P-element.