| Literature DB >> 3121370 |
N Busso1, M Collart, J D Vassalli, D Belin.
Abstract
The effect of RU 486, a synthetic steroid that is a powerful antagonist of glucocorticoid hormones, was tested on the transcription of several glucocorticoid-regulated genes in different cell types: inflammatory murine macrophages and two human mammary gland-derived cell lines, MDA-MB-231 and HBL-100. The transcription of genes which are positively regulated by glucocorticoids (e.g., tissue-type plasminogen activator and c-myc in mammary cells, c-fos in macrophages) and that of genes which are negatively regulated by these agents (e.g., urokinase-type plasminogen activator in all three cell types, TNF-a and IL-1 in macrophages) was explored. RU 486 almost completely prevented the effects of dexamethasone on the transcription of these various genes. When added alone, RU 486 had essentially no agonist activity.Entities:
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Year: 1987 PMID： 3121370 DOI： 10.1016/0014-4827(87)90282-5
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905