Jasmin Honkamäki1, Hanna Hisinger-Mölkänen2, Pinja Ilmarinen3, Päivi Piirilä4, Leena E Tuomisto3, Heidi Andersén5, Heini Huhtala6, Anssi Sovijärvi4, Helena Backman7, Bo Lundbäck8, Eva Rönmark7, Lauri Lehtimäki9, Hannu Kankaanranta10. 1. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 2. Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland. 3. Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland. 4. Unit of Clinical Physiology, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. 5. Department of Respiratory Medicine, Vaasa Central Hospital, Vaasa, Finland. 6. Faculty of Social Sciences, Tampere University, Tampere, Finland. 7. Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN Unit, Umeå University, Umeå, Sweden. 8. Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. 9. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Allergy Centre, Tampere University Hospital, Tampere, Finland. 10. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland. Electronic address: hannu.kankaanranta@epshp.fi.
Abstract
BACKGROUND: Asthma is currently divided into different phenotypes, with age at onset as a relevant differentiating factor. In addition, asthma with onset in adulthood seems to have a poorer prognosis, but studies investigating age-specific incidence of asthma with a wide age span are scarce. OBJECTIVE: To evaluate incidence of asthma diagnosis at different ages and differences between child- and adult-diagnosed asthma in a large population-based study, with gender-specific analyzes included. METHODS: In 2016, a respiratory questionnaire was sent to 8000 randomly selected subjects aged 20-69 years in western Finland. After two reminders, 4173 (52.3%) subjects responded. Incidence rate of asthma was retrospectively estimated based on the reported age of asthma onset. Adult-diagnosed asthma was defined as a physician-diagnosis of asthma made at ≥ 18 years of age. RESULTS: Among those with physician-diagnosed asthma, altogether, 63.7% of subjects, 58.4% of men and 67.8% of women, reported adult-diagnosed asthma. Incidence of asthma diagnosis was calculated in 10-year age groups and it peaked in young boys (0-9 years) and middle-aged women (40-49 years) and the average incidence rate during the examined period between 1946 and 2015 was 2.2/1000/year. Adult-diagnosed asthma became the dominant phenotype among those with physician-diagnosed asthma by age of 50 years and 38 years in men and women, respectively. CONCLUSIONS: Asthma is mainly diagnosed during adulthood and the incidence of asthma diagnosis peaks in middle-aged women. Asthma diagnosed in adulthood should be considered more in clinical practice and management guidelines.
BACKGROUND:Asthma is currently divided into different phenotypes, with age at onset as a relevant differentiating factor. In addition, asthma with onset in adulthood seems to have a poorer prognosis, but studies investigating age-specific incidence of asthma with a wide age span are scarce. OBJECTIVE: To evaluate incidence of asthma diagnosis at different ages and differences between child- and adult-diagnosed asthma in a large population-based study, with gender-specific analyzes included. METHODS: In 2016, a respiratory questionnaire was sent to 8000 randomly selected subjects aged 20-69 years in western Finland. After two reminders, 4173 (52.3%) subjects responded. Incidence rate of asthma was retrospectively estimated based on the reported age of asthma onset. Adult-diagnosed asthma was defined as a physician-diagnosis of asthma made at ≥ 18 years of age. RESULTS: Among those with physician-diagnosed asthma, altogether, 63.7% of subjects, 58.4% of men and 67.8% of women, reported adult-diagnosed asthma. Incidence of asthma diagnosis was calculated in 10-year age groups and it peaked in young boys (0-9 years) and middle-aged women (40-49 years) and the average incidence rate during the examined period between 1946 and 2015 was 2.2/1000/year. Adult-diagnosed asthma became the dominant phenotype among those with physician-diagnosed asthma by age of 50 years and 38 years in men and women, respectively. CONCLUSIONS:Asthma is mainly diagnosed during adulthood and the incidence of asthma diagnosis peaks in middle-aged women. Asthma diagnosed in adulthood should be considered more in clinical practice and management guidelines.
Authors: Jaana Takala; Iida Vähätalo; Leena E Tuomisto; Onni Niemelä; Pinja Ilmarinen; Hannu Kankaanranta Journal: NPJ Prim Care Respir Med Date: 2022-10-21 Impact factor: 3.289
Authors: Christine C Johnson; Suzanne L Havstad; Dennis R Ownby; Christine L M Joseph; Alexandra R Sitarik; Jocelyn Biagini Myers; Tebeb Gebretsadik; Tina V Hartert; Gurjit K Khurana Hershey; Daniel J Jackson; Robert F Lemanske; Lisa J Martin; Edward M Zoratti; Cynthia M Visness; Patrick H Ryan; Diane R Gold; Fernando D Martinez; Rachel L Miller; Christine M Seroogy; Anne L Wright; James E Gern Journal: J Allergy Clin Immunol Date: 2021-05-06 Impact factor: 10.793
Authors: Heidi Andersén; Pinja Ilmarinen; Jasmin Honkamäki; Leena E Tuomisto; Päivi Piirilä; Hanna Hisinger-Mölkänen; Anssi Sovijärvi; Helena Backman; Bo Lundbäck; Eva Rönmark; Lauri Lehtimäki; Hannu Kankaanranta Journal: Eur Clin Respir J Date: 2020-12-10
Authors: Heidi Andersén; Hannu Kankaanranta; Leena E Tuomisto; Päivi Piirilä; Anssi Sovijärvi; Arnulf Langhammer; Helena Backman; Bo Lundbäck; Eva Rönmark; Lauri Lehtimäki; Pinja Ilmarinen Journal: Prev Med Rep Date: 2021-02-23
Authors: Heidi Andersén; Pinja Ilmarinen; Jasmin Honkamäki; Leena E Tuomisto; Hanna Hisinger-Mölkänen; Helena Backman; Bo Lundbäck; Eva Rönmark; Tari Haahtela; Anssi Sovijärvi; Lauri Lehtimäki; Päivi Piirilä; Hannu Kankaanranta Journal: ERJ Open Res Date: 2022-01-24
Authors: Heidi Andersén; Pinja Ilmarinen; Jasmin Honkamäki; Leena E Tuomisto; Hanna Hisinger-Mölkänen; Helena Backman; Bo Lundbäck; Eva Rönmark; Lauri Lehtimäki; Anssi Sovijärvi; Päivi Piirilä; Hannu Kankaanranta Journal: J Asthma Allergy Date: 2021-09-07
Authors: Rikhard Mäki-Heikkilä; Jussi Karjalainen; Jari Parkkari; Maarit Valtonen; Lauri Lehtimäki Journal: Sports Med Date: 2020-11 Impact factor: 11.136