Literature DB >> 31211236

Complex I and MDM2: hit me baby one more time.

Jerry Edward Chipuk1,2,3,4,5.   

Abstract

MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.

Entities:  

Keywords:  Apoptosis; Complex I; MDM2; NDUFS1; mitochondria

Year:  2019        PMID： 31211236      PMCID： PMC6548488          DOI： 10.1080/23723556.2019.1607457

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.

Authors:  Jerry E Chipuk; Ulrich Maurer; Douglas R Green; Martin Schuler
Journal:  Cancer Cell       Date:  2003-11       Impact factor: 31.743

Review 2.  MDM2 and mitochondrial function: One complex intersection.

Authors:  Camila Rubio-Patiño; Andrew Paul Trotta; Jerry Edward Chipuk
Journal:  Biochem Pharmacol       Date:  2018-11-01       Impact factor: 5.858

Review 3.  Mitochondrial complex I: structure, function and pathology.

Authors:  Rolf J R J Janssen; Leo G Nijtmans; Lambert P van den Heuvel; Jan A M Smeitink
Journal:  J Inherit Metab Dis       Date:  2006-07-11       Impact factor: 4.982

4.  Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

Authors:  S N Jones; A R Hancock; H Vogel; L A Donehower; A Bradley
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

5.  A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.

Authors:  Judith Nicholson; Alex Scherl; Luke Way; Elizabeth A Blackburn; Malcolm D Walkinshaw; Kathryn L Ball; Ted R Hupp
Journal:  Cell Signal       Date:  2014-02-28       Impact factor: 4.315

6.  MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.

Authors:  Rana Elkholi; Ioana Abraham-Enachescu; Andrew P Trotta; Camila Rubio-Patiño; Jarvier N Mohammed; Mark P A Luna-Vargas; Jesse D Gelles; Joshua R Kaminetsky; Madhavika N Serasinghe; Cindy Zou; Sumaira Ali; Gavin P McStay; Cathie M Pfleger; Jerry Edward Chipuk
Journal:  Mol Cell       Date:  2019-03-14       Impact factor: 17.970

7.  Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

Authors:  Giuseppe Arena; Madi Yann Cissé; Samuel Pyrdziak; Laurent Chatre; Romain Riscal; Maryse Fuentes; Jamie Jon Arnold; Markus Kastner; Laurie Gayte; Christelle Bertrand-Gaday; Kevin Nay; Claire Angebault-Prouteau; Kerren Murray; Beatrice Chabi; Christelle Koechlin-Ramonatxo; Béatrice Orsetti; Charles Vincent; François Casas; Jean-Christophe Marine; Sandrine Etienne-Manneville; Florence Bernex; Anne Lombès; Craig Eugene Cameron; Hervé Dubouchaud; Miria Ricchetti; Laetitia Karine Linares; Laurent Le Cam
Journal:  Mol Cell       Date:  2018-02-15       Impact factor: 17.970

8.  In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.

Authors:  Lyubomir T Vassilev; Binh T Vu; Bradford Graves; Daisy Carvajal; Frank Podlaski; Zoran Filipovic; Norman Kong; Ursula Kammlott; Christine Lukacs; Christian Klein; Nader Fotouhi; Emily A Liu
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

9.  Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes.

Authors:  Irene Lopez-Fabuel; Juliette Le Douce; Angela Logan; Andrew M James; Gilles Bonvento; Michael P Murphy; Angeles Almeida; Juan P Bolaños
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-31       Impact factor: 11.205
  9 in total

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