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Literature DB >> 31211232

NAD⁺ metabolism controls inflammation during senescence.

Abstract

We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence. This newly discovered epigenetic-metabolic signaling axis, mediated by high mobility group A and nicotinamide phosphoribosyltransferase, drives key metabolic changes and pro-inflammatory responses of senescent cells that fuel cancer progression.

Entities: Chemical Disease

Keywords: Cellular senescence; HMGA; NAD+; NAMPT; senescence-associated secretory phenotype (SASP)

Year: 2019 PMID： 31211232 PMCID： PMC6548475 DOI： 10.1080/23723556.2019.1605819

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.

Authors: T F Sumter; L Xian; T Huso; M Koo; Y-T Chang; T N Almasri; L Chia; C Inglis; D Reid; L M S Resar
Journal: Curr Mol Med Date: 2016 Impact factor: 2.222

Review 2. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Authors: Luis Rajman; Karolina Chwalek; David A Sinclair
Journal: Cell Metab Date: 2018-03-06 Impact factor: 27.287

Review 3. Spatial and Temporal Control of Senescence.

Authors: Yoko Ito; Matthew Hoare; Masashi Narita
Journal: Trends Cell Biol Date: 2017-08-17 Impact factor: 20.808

4. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.

Authors: Carmen Guerra; Manuel Collado; Carolina Navas; Alberto J Schuhmacher; Isabel Hernández-Porras; Marta Cañamero; Manuel Rodriguez-Justo; Manuel Serrano; Mariano Barbacid
Journal: Cancer Cell Date: 2011-06-14 Impact factor: 31.743

Review 5. From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.

Authors: Christopher D Wiley; Judith Campisi
Journal: Cell Metab Date: 2016-06-14 Impact factor: 27.287

Review 6. Senescent cells: an emerging target for diseases of ageing.

Authors: Bennett G Childs; Martina Gluscevic; Darren J Baker; Remi-Martin Laberge; Dan Marquess; Jamie Dananberg; Jan M van Deursen
Journal: Nat Rev Drug Discov Date: 2017-07-21 Impact factor: 84.694

Review 7. NF-κB, inflammation, immunity and cancer: coming of age.

Authors: Koji Taniguchi; Michael Karin
Journal: Nat Rev Immunol Date: 2018-01-22 Impact factor: 53.106

Review 8. Two-Step Senescence-Focused Cancer Therapies.

Authors: Cynthia J Sieben; Ines Sturmlechner; Bart van de Sluis; Jan M van Deursen
Journal: Trends Cell Biol Date: 2018-05-17 Impact factor: 20.808

9. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Authors: Jean-Philippe Coppé; Christopher K Patil; Francis Rodier; Yu Sun; Denise P Muñoz; Joshua Goldstein; Peter S Nelson; Pierre-Yves Desprez; Judith Campisi
Journal: PLoS Biol Date: 2008-12-02 Impact factor: 8.029

10. NAD⁺ metabolism governs the proinflammatory senescence-associated secretome.

Authors: Timothy Nacarelli; Lena Lau; Takeshi Fukumoto; Joseph Zundell; Nail Fatkhutdinov; Shuai Wu; Katherine M Aird; Osamu Iwasaki; Andrew V Kossenkov; David Schultz; Ken-Ichi Noma; Joseph A Baur; Zachary Schug; Hsin-Yao Tang; David W Speicher; Gregory David; Rugang Zhang
Journal: Nat Cell Biol Date: 2019-02-18 Impact factor: 28.824

10 in total

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