Literature DB >> 31209376

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Kristina Valentinova1,2, Anna Tchenio1, Massimo Trusel1, Joseph A Clerke1, Arnaud L Lalive1, Stamatina Tzanoulinou3, Alessandro Matera4, Imane Moutkine5, Luc Maroteaux5, Rosa C Paolicelli4, Andrea Volterra1, Camilla Bellone3, Manuel Mameli6,7.   

Abstract

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

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Year:  2019        PMID： 31209376     DOI： 10.1038/s41593-019-0421-4

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  32 in total

1.  Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons.

Authors:  Jun Wang; Jie Li; Qian Yang; Ya-Kai Xie; Ya-Lan Wen; Zhen-Zhong Xu; Yulong Li; Tianle Xu; Zhi-Ying Wu; Shumin Duan; Han Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-16       Impact factor: 11.205

Review 2.  Circuits and functions of the lateral habenula in health and in disease.

Authors:  Hailan Hu; Yihui Cui; Yan Yang
Journal:  Nat Rev Neurosci       Date:  2020-04-08       Impact factor: 34.870

3.  Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula.

Authors:  Yoshiko Hashikawa; Koichi Hashikawa; Mark A Rossi; Marcus L Basiri; Yuejia Liu; Nathan L Johnston; Omar R Ahmad; Garret D Stuber
Journal:  Neuron       Date:  2020-04-08       Impact factor: 17.173

4.  Mu-Opioid Receptors Expressed in Glutamatergic Neurons are Essential for Morphine Withdrawal.

Authors:  Xin-Yan Zhang; Qing Li; Ye Dong; Wei Yan; Kun Song; Yong-Qin Lin; Yan-Gang Sun
Journal:  Neurosci Bull       Date:  2020-05-25       Impact factor: 5.203

5.  Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension.

Authors:  Clara Woods; Jose Marques-Lopes; Natalina H Contoreggi; Teresa A Milner; Virginia M Pickel; Gang Wang; Michael J Glass
Journal:  J Neurosci       Date:  2020-12-10       Impact factor: 6.167

6.  Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice.

Authors:  Isabel M Bravo; Brennon R Luster; Meghan E Flanigan; Patric J Perez; Elizabeth S Cogan; Karl T Schmidt; Zoe A McElligott
Journal:  Eur J Neurosci       Date:  2019-10-06       Impact factor: 3.386

Review 7.  The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models.

Authors:  Lola Welsch; Julie Bailly; Emmanuel Darcq; Brigitte Lina Kieffer
Journal:  Biol Psychiatry       Date:  2019-08-06       Impact factor: 13.382

8.  Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats.

Authors:  Ludovic D Langlois; Rina Y Berman; Ryan D Shepard; Sarah C Simmons; Mumeko C Tsuda; Shawn Gouty; Kwang H Choi; Fereshteh S Nugent
Journal:  Addict Biol       Date:  2021-05-25       Impact factor: 4.280

Review 9.  Microglia in depression: current perspectives.

Authors:  Xiaoning Jia; Zhihua Gao; Hailan Hu
Journal:  Sci China Life Sci       Date:  2020-10-14       Impact factor: 6.038

10.  Acetaldehyde Excitation of Lateral Habenular Neurons via Multiple Cellular Mechanisms.

Authors:  Weiyuan Huang; Wanhong Zuo; Lixin Chen; Liwei Wang; George Tewfik; Rao Fu; Jiayi Zheng; Ding Li; Jiang-Hong Ye
Journal:  J Neurosci       Date:  2021-07-29       Impact factor: 6.167
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