Penélope Esther Palominos1, Ana Paula Beckhauser de Campos2, Sandra Lúcia Euzébio Ribeiro3, Ricardo Machado Xavier4,5, Jady Wroblewski Xavier5, Felipe Borges de Oliveira5, Bruno Guerra5, Carla Saldanha4, Aline Castello Branco Mancuso6, Charles Lubianca Kohem4,5, Andrese Aline Gasparin4, Percival Degrava Sampaio-Barros7. 1. Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos 2350, sexto andar, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil. penelopepalominos@gmail.com. 2. Serviço de Reumatologia, Hospital Universitário Evangélico, Alameda Augusto Stellfeld, 1908, Bigorrilho, Curitiba, Paraná, CEP 80730-150, Brazil. 3. Serviço de Reumatologia, Hospital Universitário Getúlio Vargas, Universidade Federal do Amazonas, Avenida Apurinã 4, Manaus, Amazonas, CEP 69020-170, Brazil. 4. Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos 2350, sexto andar, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil. 5. Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2400, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil. 6. Departamento de Bioestatística, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul, CEP 90035-903, Brazil. 7. Serviço de Reumatologia, Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Abstract
BACKGROUND: The presence of enthesitis is associated with higher disease activity, more disability and incapacity to work and a poorer quality of life in spondyloarthritis (SpA). There is currently no consensus on which clinical score should be used to assess enthesitis in SpA. The objective of the present work was to compare the correlation of three enthesitis indices (MASES, SPARCC and LEI) with measures of disease activity and function in a heterogeneous population of patients with axial and peripheral SpA. METHODS: A cross-sectional study was conducted in three Brazilian public university hospitals; patients fulfilling ASAS classification criteria for peripheral or axial SpA were recruited and measures of disease activity and function were collected and correlated to three enthesitis indices: MASES, SPARCC and LEI using Spearman's Correlation index. ROC curves were used to determine if the the enthesitis indices were useful to discriminate patients with active disease from those with inactive disease. RESULTS: Two hundred four patients were included, 71.1% (N = 145) fulfilled ASAS criteria for axial SpA and 28.9% (N = 59) for peripheral SpA. In axial SpA, MASES performed better than LEI (p = 0.018) and equal to SPARCC (p = 0.212) regarding correlation with disease activity (BASDAI) and function (BASFI). In peripheral SpA, only MASES had a weak but statistical significant correlation with DAS28-ESR (rs 0.310 p = 0.05) and MASES had better correlation with functional measures (HAQ) than SPARCC (p = 0.034). CONCLUSION: In this sample composed of SpA patients with high coexistence of axial and peripheral features, MASES showed statistical significant correlation with measures of disease activity and function in both axial and peripheral SpA.
BACKGROUND: The presence of enthesitis is associated with higher disease activity, more disability and incapacity to work and a poorer quality of life in spondyloarthritis (SpA). There is currently no consensus on which clinical score should be used to assess enthesitis in SpA. The objective of the present work was to compare the correlation of three enthesitis indices (MASES, SPARCC and LEI) with measures of disease activity and function in a heterogeneous population of patients with axial and peripheral SpA. METHODS: A cross-sectional study was conducted in three Brazilian public university hospitals; patients fulfilling ASAS classification criteria for peripheral or axial SpA were recruited and measures of disease activity and function were collected and correlated to three enthesitis indices: MASES, SPARCC and LEI using Spearman's Correlation index. ROC curves were used to determine if the the enthesitis indices were useful to discriminate patients with active disease from those with inactive disease. RESULTS: Two hundred four patients were included, 71.1% (N = 145) fulfilled ASAS criteria for axial SpA and 28.9% (N = 59) for peripheral SpA. In axial SpA, MASES performed better than LEI (p = 0.018) and equal to SPARCC (p = 0.212) regarding correlation with disease activity (BASDAI) and function (BASFI). In peripheral SpA, only MASES had a weak but statistical significant correlation with DAS28-ESR (rs 0.310 p = 0.05) and MASES had better correlation with functional measures (HAQ) than SPARCC (p = 0.034). CONCLUSION: In this sample composed of SpA patients with high coexistence of axial and peripheral features, MASES showed statistical significant correlation with measures of disease activity and function in both axial and peripheral SpA.
Authors: X Baraliakos; P Sewerin; E de Miguel; E Pournara; C Kleinmond; A Shekhawat; C Jentzsch; A Wiedon; F Behrens Journal: Arthritis Res Ther Date: 2022-05-16 Impact factor: 5.606
Authors: Michael J Nissen; Burkhard Möller; Adrian Ciurea; Ruediger B Mueller; Patrick Zueger; Martin Schulz; Fabiana Ganz; Almut Scherer; Eleftherios Papagiannoulis; Thomas Hügle Journal: Arthritis Res Ther Date: 2021-06-09 Impact factor: 5.156